METHODS USED IN ACTIVE AND PASSIVE TARGETING OF NANO CARRIERS TO CANCER CELLS
Journal Title: Kocatepe Medical Journal - Year 2024, Vol 25, Issue 3
Abstract
With the developments in nanotechnology, nanomaterial-based drug delivery systems with their increasing and ease of use, have powerful properties in targeting drug molecules to tumor tissue, breaking multi-drug resistance in tumor cells and improving the dose-dependent reduced therapeutic effect. In recent years, interest in nanomaterials has been increasing with the development of new methods and approaches based on nanotechnology in anticancer treatment strategies targeting many types of cancer. With the rapid progress of developments in nanotechnology, the integration of nanomaterials into cancer therapeutics and the specific targeting of markers on the surfaces of cancer cells have provided revolutionary improvements in cancer treatment. Due to drug loading in nanocarrier systems, drug delivery systems can be redesigned by changing the sizes, morphologies and surface chemistry of the components with various methods for improved drug half-life, controlled and selective drug release, which reduces the toxicity caused by increased drug loading in the body. Thus, custom-made nanomaterials can predictably target cancer cells, effectively delivering the loaded drugs to the cancer cell. So far, polymeric nanomaterials, metallic nanoparticles, carbon-based materials, liposomes and dendrimers have been produced for use in smart drug delivery systems with superior pharmacokinetic and pharmacodynamic profiles prepared compared to conventional formulations due to their nanoscale dimensions and versatile physicochemical properties in cancer therapy. In this review, it is aimed to reveal the advantages and disadvantages of the physicochemical, pharmacokinetic and pharmacodynamic properties of various drug delivery systems, including nanoparticles, micelles, carbon nanotubes, dendrimers, quantum dots and liposomes, which are used as the basis for the creation of drug delivery systems. In addition, the application areas of two different drug transport methods, passive and active transport, in cancer treatment are discussed, and it creates a perspective for those interested in the subject in terms of the use of nanocarrier systems in future clinical studies.
Authors and Affiliations
İsmail Mert ALKAÇ, Seda KESKİN, Burcu ÇERÇİ
Keywords
Related Articles
- EP ID EP740672
- DOI https://doi.org/10.18229/kocatepetip.992813
- Views 18
- Downloads 1
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