MicroRNAs: properties and role in the development and progression of non-alcoholic fatty liver disease
Journal Title: Сучасна гастроентерологія - Year 2018, Vol 0, Issue 6
Abstract
MicroRNAs (miRNAs) are the small non-coding RNAs that regulate multiple physiological and pathological processes through the modulation of gene expression at the post-transcriptional level. The role of miRNAs has been proved in the development and pathogenesis of liver disease, specifically, non-alcoholic fatty liver disease (NAFLD). The possibility of using micro-RNA as diagnostic markers has been discussed. The article consists and summarizes the data of literature investigating the role of miRNAs in NAFLD. The potential use of miRNAs as diagnostic biomarkers is discussed. Among a big number of miRNAs, miR-34a, miR-122 and miR-155 are mostly involved in NAFLD pathogenesis.
Authors and Affiliations
G. D. Fadieienko, T. L. Mozhyna, I. E. Kushnir, V. M. Chernova, T. A. Solomentseva
Keywords
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- EP ID EP454187
- DOI 10.30978/MG-2018-6-72
- Views 104
- Downloads 0
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