MicroRNAs: properties and role in the development and progression of non-alcoholic fatty liver disease
Journal Title: Сучасна гастроентерологія - Year 2018, Vol 0, Issue 6
Abstract
MicroRNAs (miRNAs) are the small non-coding RNAs that regulate multiple physiological and pathological processes through the modulation of gene expression at the post-transcriptional level. The role of miRNAs has been proved in the development and pathogenesis of liver disease, specifically, non-alcoholic fatty liver disease (NAFLD). The possibility of using micro-RNA as diagnostic markers has been discussed. The article consists and summarizes the data of literature investigating the role of miRNAs in NAFLD. The potential use of miRNAs as diagnostic biomarkers is discussed. Among a big number of miRNAs, miR-34a, miR-122 and miR-155 are mostly involved in NAFLD pathogenesis.
Authors and Affiliations
G. D. Fadieienko, T. L. Mozhyna, I. E. Kushnir, V. M. Chernova, T. A. Solomentseva
Keywords
Related Articles
- EP ID EP454187
- DOI 10.30978/MG-2018-6-72
- Views 111
- Downloads 0
Predictors of irritable bowel syndrome formation among students
Objective — to establish the role of the nervous system disorders in the formation of irritable bowel syndrome (IBS) among students. Materials and methods. Examination involved 32 students with IBS, aged 19 to 26 years....
Practical approaches to the optimization of diagnostics and treatment of Helicobacter pylori infection in Ukraine
The article outlines the main provisions of the Maastricht Consensus V (2015) concerning management of the H. pylori-infected patients. With account of the current scientific data, the practical recommendations for optim...
Efficiency and safety of ademetionine in the correction of liver function in patients with steatohepatitis. The results of an open comparative post-marketing study.
Objective — to study the efficacy and safety of ademetionine in patients with non-alcoholic steatohepatitis (NASH). Materials and methods. Examinations involved 60 patients with NASH, who were divided into two groups. Pa...
Helicobacter pylori infection among the adults of Vinnytsya region, patients with nonatrophic and atrophic chronic gastritis
Objective — to assess the degree of Helicobacter pylori infection among the adult patients with chronic gastritis (CG) and its relationship with atrophic changes in the gastric mucosa. Materials and methods. The examina...
Nutrigenetic characteristics of patients with nonalcoholic liver disease combined with metabolic syndrome
Objective — to detect possible association of polymorphisms of the Pro12Ala of PPARG2 gene (rs1801282) and ADRB3 gene (rs4994) with a degree of fatty liver and metabolic disorders in patients with NAFLD. Materials and m...