Miller Fisher Syndrome Presenting with Idiopathic Central Serous Chorioretinopathy: A Rare Association
Journal Title: International Journal of Contemporary Medical Research - Year 2018, Vol 5, Issue 6
Abstract
Introduction: Miller Fisher syndrome is a rare autoimmune disorder characterized with acute onset of diplopia, bilateral complete ophthalmoplegia, ataxia and areflexia. It is a variant of Guillian Barre Syndrome and carries a risk of progression to GBS in rare instances. But unlike GBS, MFS is a selflimiting condition with annual incidence of 0.09/100,000 populations, and because of its similarity with GB syndrome, prompt diagnosis and follow-up is required. Typical MFS has never been reported previously with Idiopathic Central Serous chorioretinopathy [ICSC]. Case report: 40 years old male presented with sudden onset diminution of vision, diplopia and associated neurological features suggestive of MFS. B.P. at the time of presentation was 150/100mm of Hg with no prior history of hypertension. On further evaluation patient was diagnosed with ICSC right eye along with MFS. Patient was managed with supportive treatment and systemic steroid was avoided. Patient recovered completely by 4th week. Conclusion: MFS is autoimmune neurological condition presenting as GBS. Because of its rarity, good clinical knowledge of this condition is essential for prompt diagnosis and management. MFS patients only require supportive treatment till complete neurological recovery. But rare severe cases may require immunosuppressive treatment. Association of ICSC with autoimmune conditions like Systemic Lupus Erythematous(SLE), Anti-phospholipid Ab syndrome is well known but association with MFS has never been reported earlier. In present case, association of ICSC with MFS and its resolution with resolution of systemic disease suggest some common pathophysiology, which needs further study.
Authors and Affiliations
Harsh Vardhan Singh, Shubhra Das
Keywords
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