Modifed Goff Symptom Index Simple triage tool for ovarian malignancy
Journal Title: Sultan Qaboos University Medical Journal - Year 2015, Vol 15, Issue 3
Abstract
Objectives: Ovarian cancer often goes undiagnosed or misdiagnosed in the early stages. Te present study aimed to validate a modifed version of the Goff Symptom Index (GSI) in an Indian population. Methods: Tis prospective case-control study was conducted between July 2010 and June 2012 in a university hospital in Manipal, Karnataka, India. A total of 305 inpatients admitted for ovarian pathology investigations and outpatients undergoing routine gynaecological check-ups were included in the study. Te modifed GSI (MGSI) was used to investigate the presence, severity, frequency and duration of 10 ovarian cancer symptoms on a scale of 1–5. Four additional symptoms were included with those of the original GSI (two symptoms from a previous MGSI and two new symptoms). Patients were regarded as positive for ovarian cancer if symptoms occurred >12 times per month and time since onset was <1 year. Histopathology confrmed the diagnosis of ovarian tumours. Results: A total of 13 patients were excluded. Te fnal sample (n = 292) was divided into a test group (n = 74) and a control group (n = 218) based on histopathology. Within the controls, 144 women were found to have benign tumours. Te MGSI was positive in 71.6% of the test group as opposed to only 11.5% of the control group. Te addition of two symptoms (loss of appetite and weight) to the GSI increased the test’s sensitivity from 71.6% to 77% without compromising specifcity (88.5%). Conclusion: Based on these fndings, the addition of two new symptoms (loss of appetite and weight) to the GSI is proposed in order to increase the test’s sensitivity. However, the addition of urinary symptoms to the GSI requires further validation.
Authors and Affiliations
Jyothi Shetty| Department of Obstetrics & Gynecology, Kasturba Medical College, Manipal, Karnataka, India, Priyadarshini P. | Department of Obstetrics & Gynecology, Kasturba Medical College, Manipal, Karnataka, India, Deeksha Pandey| Department of Obstetrics & Gynecology, Kasturba Medical College, Manipal, Karnataka, India, Manjunath A. P. | Department of Obstetrics & Gynaecology, Sultan Qaboos University Hospital, Muscat, Oman
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