Molar Pregnancy with False Negative urine β-HCG: Hook effect in molar pregnancy
Journal Title: International Journal of Pharmaceutical and Medicinal Reserach - Year 2014, Vol 2, Issue 5
Abstract
Urine pregnancy test is widely used in emergency department as the first screening test for patients of reproductive age presenting with gynaecological problem in order to rule out pregnancy. Conditions such as complete molar pregnancy which produces large amount of serum beta Human chorionicgonadotrophin (β hCG), may cause a false negative result due to oversaturation of the assay system known as the “Hook Effect”. We report a case where the exclusion of pregnancy by urine test lead to initial misdiagnosis of molar pregnancy. The patient demonstrated clinical features of hydatidiform mole, despite multiple negative urine pregnancy tests. These false- negative qualitative human chorionic gonadotropin assays were likely caused by the “high – dose Hook Effect”. Gynaecologists need to be reminded of the possibility of false negative result with this commonly used test.
Authors and Affiliations
Anuradha Salvi, Premlata Mital, Usha Shekhawat, Alka Batar, Priyanka Makkar, Pradeep Kumar Soni
Keywords
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