Molecular Imaging in Sarcoidosis and Amyloidosis
Journal Title: Nükleer Tıp Seminerleri - Year 2018, Vol 4, Issue 2
Abstract
Sarcoidosis and amyloidosis can affect many organs, including the heart. The diagnosis of cardiac sarcoidosis and amyloidosis is very important because the prognosis of the patient depends on cardiac involvement and early treatment. Radionuclide molecular imaging plays an important role in the evaluation of these patients. Advances in noninvasive imaging methods have reduced the need for endomyocardial biopsy in patients with sarcoidosis and amyloidosis. Early diagnosis and appropriate treatment of cardiac sarcoidosis improve the prognosis of patients. F-18 fludeoxyglucose positron emission tomography (PET) imaging in patients with cardiac sarcoidosis is useful in diagnosis, prediction of risk and prognosis, choice of treatment, and in monitoring the response to treatment. PET imaging with somatostatin analogues in cardiac sarcoidosis shows promising results. Identification of myocardial involvement in amyloidosis and discrimination of amyloid subtypes is the most important step. Bone scintigraphy and PET imaging with amyloid-specific tracers may be an appropriate choice to identify cardiac amyloidosis and differentiate subtypes. In this review, radionuclide molecular imaging in cardiac sarcoidosis and cardiac amyloidosis is described.
Authors and Affiliations
Koray Demirel, Meliha Korkmaz
Keywords
Related Articles
- EP ID EP382273
- DOI -
- Views 113
- Downloads 0
Nuclear Medicine Procedures in Diagnosis of Infective Endocarditis
Infective endocarditis (IE) is described as infection of the endocardial surfaces of the heart and if available prosthesis materials. Despite all up-to-date developments in diagnosis and treatment, IE is a mortal and mor...
Natural and Artificial Radiation Sources and Personal Dose Additives
Radiation is defined as the energy in motion. Since the creation of the universe, all living creatures and humans are exposed to radiation in more or less levels. There is radioactivity naturally in the air, in the foods...
The Role of Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Imaging in Mesothelioma
Mesothelioma is a highly aggressive neoplasm originating from mesothelial cells in serosal surfaces and mostly (90%) from pleura. Exposure to asbestos and erionite fibers plays an important role in pleural mesothelioma e...
Possible Role of Ga-68 PSMA PET/CT in Evaluation of Systemic Treatment Response in Patients with Metastatic Prostate Cancer
Despite the move toward molecular diagnostics, our clinical imaging paradigms for diagnosing cancer and for monitoring cancer therapy have largely remained at the anatomical rather than the cellular or molecular level. I...
Experimental Animal Models for Lung Cancer
Lung cancer is the most lethal type of cancer after initial diagnosis. Clinically more suitable systems are needed for examination of both non-small cell lung cancer and small cell lung cancer biology and for characteriz...