Molecular Mechanics Simulation and Ftir Spectrocopy Optimization of Secondary Structure of Aβ (25-35) Peptide
Journal Title: Scientific Work - Year 2024, Vol 18, Issue 9
Abstract
Abstract In this study, we probed the secondary structure of a soluble Aβ (25-35) peptide in water solution by applying a molecular mechanics method as well as infrared spectroscopy. We have used Fourier Transformed Infrared Spectroscopy (FTIR) to examine the secondary structure of this peptide. The amide I bands of Ab (25-35) obtained from transmission-FTIR spectra consists of one main band at 1658 cm-1, at both concentrations used (200 mM and 1 mM). This band shows us that Ab (25-35) in aqueous solution was mostly organized into a a-helical structure (48 %). The contribution of the unordered structure was found to be about 12 %. The proportion of b-sheet and b-turn structures are slightly lower, 12-15 % and 13-14 %, respectively for both concentrations. FTIR spectra of the peptide in water solution (100 µM) after incubation for 12h showed Aβ peptide conformation is critically dependent on the environmental conditions used. The simulation approach reveals that the C-terminal octapeptide of this molecule preferably adopts an α-helical structure, while the N-terminal tripeptide may exist as a β-turn and unordered structures.
Authors and Affiliations
Gulyaz Najafova French-Azerbaijani University (UFAZ) under the Azerbaijan State Oil and Industry University Ph. D. student Gulshan Aghayeva Scientific Research Institute of Physics Problems at Baku State University
Keywords
Related Articles
- EP ID EP747388
- DOI 10.36719/2663-4619/106/45-52
- Views 39
- Downloads 0
PREDICTING FINANCIAL INFORMATION BY USING SUPERVISED MACHINE LEARNING METHODS
Abstract The use of technology in finance is a rising trend. Although this may seem like an advantage, it also brings with it a great responsibility, because if financial institutions fall behind in technology, it wil...
RIGHT TO LIFE AND RIGHT TO HEALTH AS COMPONENTS OF RIGHT TO PEACE
When we look at the history of the world, there are short periods without wars, conflicts, and destruction, but generally, there is no period in which peace, as we understand it, lasts for centuries. The policies of stat...
BRETTON WOOD ACCORDS AND FOMATION OF IMF AND WB
Abstract The Bretton Woods system was a monetary management system established in 1944, in the aftermath of World War II. Under the Bretton Woods system, other countries could exchange their dollars for gold at a fixe...
HAYAO MİYAZAKİ YARADICILIĞINDA DİNİ MOTİVLƏRİN TƏZAHÜRÜ
Hayao Miyazakinin filmlərində bəzi dini motivlərin izlərini görmək mümkündür. Miyazakinin əsərləri tez-tez Şintoizm, Buddizm və fövqəltəbii inanclar kimi Yapon mədəniyyətinin elementlərini əks etdirir. Bu elementlər bəzə...
STUDY ON CHINA’S EXPORT POTENTIAL TO CENTRAL ASIA IN THE BACKGROUND OF THE BELT AND ROAD INITIATIVE (BRI)
In the context of COVID-19, international trade has been strongly affected, and it is of great importance to accelerate trade with countries along with the “Belt and Road Initiative” to achieve business transformation. T...