MONOCAPRYLIN AND DICAPRYLIN PRODUCTION BY IMMOBILIZED LIPASE USING BATCH AND FED-BATCH OPERATING MODES
Journal Title: WORLD JOURNAL PHARMACY AND PHARMACEUTICAL SCIENCE - Year 2019, Vol 8, Issue 11
Abstract
Esterification of glycerol (G) with caprylic acid (CA) catalyzed by immobilized lipases (Lipozyme IM and Palatase® - 1X2-400) was carried out in a 125 mL bench reactor operated at batch and fed-batch mode. Tests were planned following a complete factorial design, with temperature (30oC and 70oC), reaction time (6h and 10h), and initial CA/G ratio (1:1 and 3:1) as variables for batch mode, whereas filling-up time (2h and 5h) and exponential addition constant (0.2h-1 and 0.8h-1) were the variables for fed-batch mode. Monocaprylin and dicaprylin yields were about 69% and 31% for batch and fed-batch, respectively. The highest amount of monocaprylin (49%) and dicaprylin (19%) occurred in batch test at 30oC and 1:1 initial CA/G ratio, conducted for 6h or 10h. Fed-batch mode led to monocaprylin yields between 14% -24% and dicaprylin yields between 11% - 16%.
Authors and Affiliations
Prof. Michele Vitolo
Keywords
Related Articles
- EP ID EP669855
- DOI -
- Views 135
- Downloads 0
COMPARISON OF NMP22 URINARY MARKER TEST AND URINE CYTOLOGY IN THE EARLY DETECTION OF RECURRENT TRANSITIONAL CELL CARCINOMA OF URINARY BLADDER
Background: Urinary Bladder Cancer is the second most common cancer treated by urologists. Its incidence is increasing with age and exposure to environmental toxins. Smoking is a known risk factor. the gold standard of d...
PRESCRIBING PATTERNS OF ANTI BIOTIC FOR CHILDREN BEFORE ADMISSION IN PEDIATRIC WARDS OF TIKRIT TEACHING HOSPITAL.
Anti – Biotic are commonly prescribed drugs in pediatrics. However the threat of anti – biotic resistance among children is cause for concern. Antibiotic resistance occurs when an antibiotic has lost its ability to effec...
MANAGEMENT OF SPEECH DISORDER IN CHILDREN THROUGH SHIROTHALAM
Among various types of developmental disabilities, the prevalence of speech disorder in India is 9.6 percent occurs mostly between ages of 5-12 in school age children. Speech disorders of childhood includes apraxia of sp...
SIMULTANEOUS DETERMINATION OF ANAESTHETIC AND ANTIBOTIC IN FLUID BY ELECTOCHEMILUMINESCENCE COUPLING CAPILLARY ELECTROPHORESIS
The coupling of electrochemiluminescence (ECL) with capillary electrophoresis (CE) was developed for the simultaneous determination of lidocaine and lomefloxacin in human urine. Under the optimized conditions: ECL detect...
POSSIBLE ROLE OF ANTIOXIDANT IN THE MANAGEMENT OF ACUTE ISCHEMIC STROKE: A REVIEW OF THE LITERATURE
Cerebrovascular disease or stroke is a major cause of morbidity and mortality all over the world. It is ably described with the initials 6:6:6, meaning: 6 million people die every year from a stroke, every 6 seconds some...