Morphological analysis of coronary atherosclerosis by modified American heart association classification in young individuals- An autopsy study
Journal Title: Medpulse International Journal of Pathology - Year 2018, Vol 8, Issue 2
Abstract
Background and Objectives: Coronary artery disease has emerged as new epidemic affecting Indians at relatively younger age with severe and diffuse form of disease. This autopsy study was conducted in young individuals to assess the morphological changes in coronary arteries and classify the atherosclerotic lesions by using modified American heart association (AHA) classification and to estimate prevalence of coronary atherosclerosis. Materials and Methods: Hundred heart specimens of subjects aged 15 to 34 years were included in study. Sections from proximal and distal part of left anterior descending artery, left circumflex artery and right coronary artery were given. Microscopic typing of atherosclerotic lesions was done by modified AHA classification. Statistical analysis was done and chi-square test was used to see the association. Results: Out of 100 cases, 65% were males and 35% were females. Among 54% cases with atherosclerosis, 19% cases showed advanced lesions. The prevalence and severity of atherosclerosis was more in males (63.04%) compared to females (37.14%). Left anterior descending artery was most commonly involved by atherosclerosis. Intimal xanthoma was most common lesion overall. Pathological intimal thickening was most common atherosclerotic lesion. Fibrous cap atheroma was most common advanced lesion. Thin fibrous cap atheroma and inflammation which are indicators of vulnerable plaques, were significantly more in males compared to females. Conclusion: The modified AHA classification has more clinical implications and offers better categorization of atherosclerotic lesions. The increased prevalence of atherosclerosis (advanced and intermediate lesions) found in young population gives an indication that preventive measures need to be implemented.
Authors and Affiliations
B J Bhandari, M N Jadhav, A K Shetty, S K Kittur
Keywords
Related Articles
- EP ID EP457193
- DOI 10.26611/105825
- Views 71
- Downloads 0
Assessment of the knowledge of blood transfusion among nursing staff: before and after implementing a designed teaching session about blood transfusion
Background: Blood is a precious resource that needs to be prescribed, handled, stored and transfused as per guidelines to ensure recipient safety. The present study aims to assess the basic knowledge of nurses pertaining...
A study of head and neck lesions in a tertiary care hospital
Background: Head and neck lesions include a spectrum of pathological lesions ranging from simple benign to highly malignant entities. These lesions contribute significantly to morbidity and mortality of patients. Aims an...
Histopathological study on mastectomy specimens in a rural population Karaikal
Background: Breast carcinoma is the most common malignant tumor in female population. In developed countries early detection and treatment has led to the sharp decline in breast cancer mortality. But in developing countr...
A study of clinical profile of patients with mesenchymal tumour of gastrointestinal tract at SVIMS, Tirupati
Background: Although relatively rare, Gastrointestinal stromal tumors (GISTs), make up the largest subset of mesenchymal tumors of the gastrointestinal tract. GIST is known for its wide variability in biological behaviou...
Clinicohematological study of pancytopenia - A study of 500 cases
Background: Pancytopenia can be due to decrease in hematopoietic cell production in the bone marrow e.g. infections, toxins, malignant cell infiltration, suppression or can have normocellular or even hypercellular marrow...