MORPHOLOGICAL CHANGES OF RAT PITUITARY- ADRENAL SYSTEM AFTER THERMAL INJURY
Journal Title: Ukrainian Scientific Medical Youth Journal / Український Науково-Медичний Молодіжний Журнал - Year 2013, Vol 76, Issue 4
Abstract
on the experimental model of the local thermal burn we investigated reactive changes of the pituitary-adrenal system in rats. In burned rat installed nonspecific destructive changes parenchymal and stromal elements of the adenohypophysis and adrenal glands. Changes characterized three phases of the development of organ dysfunction: 1-3 days – microcirculatory disorders and degenerative changes of initiation; 7-14 day – the progression of degenerative changes and stabilization; 21- 30 day – activation of regenerative processes and hemodynamics. In the pathogenesis of burn injury leading place has regional hemodynamic changes. Microcirculation disturbance cause ischemic cell injury, development of dystrophic disorders and in critical hypoxia caused tissue necrosis.
Authors and Affiliations
A. I. Kovalchuk, I. V. Dzevulska, V. N. Titarenko, A. V. Malikov
Keywords
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