MOST OF THE HELICOBACTER PYLORI ISOLATES ARE RESISTANT TO LEVOFLOXACIN IN NORTH INDIA
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2016, Vol 8, Issue 1
Abstract
Objective: Helicobacter pylori related gastro-duodenal diseases can be cured by proper treatment therapy. In India, the commercially available classic treatment therapy (proton pump inhibitor, amoxicillin, and clarithromycin) for bacterial eradication is available. However, antibiotic resistance to the commonly used triple regimen is increasing very rapidly. Considering that treatment including levofloxacin may be an alternative to the classic regimen. Therefore, we aimed to verify H. pylori isolates susceptibility to levofloxacin in India.Methods: H. pylori were cultured from 56 patients suffering from different gastro-duodenal diseases. Minimum Inhibitory concentration to levofloxacin was determined by agar dilution method.Results: The clinical diagnosis of 56 patients who were H. pylori culture positive were Gastro Esophageal Reflux Disease (GERD) (n=23), Non-erosive reflux Disease (NERD) (n=22), Non Ulcer Dyspepsia (NUD) (n=3), Antral Gastritis (n=2), Duodenal ulcer (n=1) and others (n=5). Of the 56 H. pylori isolates, the prevalence of levofloxacin resistance was found in 41 H. pylori isolates (73.2%). Conclusion: We found that three-fourth of the isolated H. pylori strains of North India showed resistance to levofloxacin which is used for H. pylori treatment in other countries. Therefore, the conventional triple therapy comprising amoxicillin and clarithromycin is more appropriate for anti H. pylori management in India.Â
Authors and Affiliations
Valentina Gehlot, Shweta Mahant, Kunal Das, Rajashree Das
Keywords
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