SYMBIOTIC ENHANCES GUT MUCOSA RECOVERY RATE AND REDUCES OVERGROWTH OF BACTERIA IN EXPERIMENTAL PROTEIN MALNUTRITION
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 5
Abstract
Objective: Investigate the effect of symbiotic on the recovery of bowel atrophy and bacterial translocation (BT) induced by protein malnutrition (PM) in rats.Methods: Rats were fed protein-deficient diet (maize) or the standard diet (standard rat chow) for 15 days. On day 10, rats fed with the protein-deficient diet were subdivided into three groups for reconstitution with protein-rich diet and Symbiotic. Milk-MTZ group, received milk+Metronidazole for 5 days and Symbiotic group, fed with some diet and probiotics-oligofructosaccharide for 5 days. Body weight was monitored daily, and all animals were sacrificed on day 15, and intestinal microflora and bacterial translocation (BT) to mesenteric lymph nodes (MLN) were evaluated. Histological studies were carried out to evaluate villi length and intra epithelial lymphocyte (IEL) infiltration.Results: Our results show the symbiotic group (n=6) having the greater gain in body weight (12% increase) than milk-MTZ-fed group (n=6, 0.61 % increase). Overgrowth of Enterobacteria in protein-deficient diet rats was higher than in controls (p<0.0001); whereas, significantly decreasing in symbiotic fed group (p<0.0001). There was no significant difference in bacterial translocation between rats fed protein-deficient diet and those fed symbiotic rich diet. However, gut mucosa recovery was greater in symbiotic group (49.24 %).Conclusion: Our data suggests that symbiotic-rich diet induces an important gain in weight and leads to better recovery of gut mucosa, but without altering bacterial translocation rate induced by the protein-deficient diet.Â
Authors and Affiliations
Hanane Gourine, Wafaa Dib, Hadria Grar, Benmhel Benakriche, Djamel Saidi, Omar Kheroua
Keywords
Related Articles
- EP ID EP578786
- DOI -
- Views 69
- Downloads 0
DESIGN AND EVALUATION OF BUCCOADHESIVE CONTROLLED RELEASE FORMULATIONS OF PROCHLORPERAZINE MALEATE
Objective: The Purpose of this work was to design mucoadhesive tablets of prochlorperazine maleate to release the drug in buccal cavity for an extended period of time in order to avoid the first-pass metabolism.Methods:...
A COMPARATIVE EVALUATION ON THE EFFECT OF ZINC-PROBIOTIC AND PROBIOTIC THERAPY IN PAEDIATRIC ACUTE DIARRHOEA AND THE IMPACT OF COUNSELLING OF MOTHERS
Objective: To compare the efficacy of zinc-probiotic combination therapy and probiotic therapy alone in the treatment of acute paediatric diarrhoea and to assess the knowledge, attitude and practice (KAP) of the mothers...
KINETIC MODELING OF RASAGILINE MESYLATE FROM NANOSCALE SOLID LIPID PARTICLES
Objective: The present study is aimed to investigate the In-vitro release behavior of the Rasagiline mesylate loaded nanoscale solid lipid particles to provide the quality based controlled release system. Methods: The Ra...
CHRONIC ORAL TOXICITY STUDIES OF CRUDE ETHANOLIC EXTRACT AND ETHANOLIC FRACTION OF PELLIONIA HEYNEANA WEDD. LEAF IN WISTAR RATS
Objective: Pellionia heyneana Wedd. leaf has been used by the Cholanaikan tribe as a traditional medicine to enhance immunity and also to treat various liver ailments. However, no scientific reports are available regardi...
A COMPARATIVE STUDY ON THE EFFECT OF FLUOROQUINOLONES IN EXPERIMENTAL SEIZURES ON WISTAR RATS: AN ACUTE STUDY
Objective: To compare the convulsive profile of three different Fluoroquinolones namely Ciprofloxacin, Levofloxacin and Ofloxacin using Maximal Electro Shock (MES) as an experimental seizure model.Methods: Wistar rats we...