Motor Deterioration Of Parkinsons Disease Due To Infection In A Geriatric Indevidual:A Diagnostic And Therapeutic Challenge.
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 11
Abstract
Clinicians are well aware of the fact that patients with Parkinson’s disease may significantly deteriorate following systemic infection or, in its most severe case, may even develop an akinetic crisis. Although this phenomenon is widely observed and has a major impact on the patients’ condition, the knowledge about the underlying mechanisms behind is still sparse. Possible explanations encompass changes in the pharmacodynamics of the dopaminergic drugs, altered dopamine metabolism in the brain, alterations in the dopaminergic transmission in the striatum or an enhancement of neurodegeneration due to remote effects of peripheral inflammatory processes or circulating bacterial toxins.
Authors and Affiliations
Raja Bhattacharya, Tapabrata Das, Subhadip Basak, Sabyasachi Roy, Angshuman Roy, Kajal Kora
Keywords
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