MOUTH DISSOLVING TABLETS CHALLENGES, PREPARATION STRATEGIES WITH A SPECIAL EMPHASIS ON LOSARTAN POTASSIUM – A REVIEW
Journal Title: WORLD JOURNAL PHARMACY AND PHARMACEUTICAL SCIENCE - Year 2018, Vol 7, Issue 9
Abstract
The main purpose of this review article is to provide complete information about the mouth dissolving/disintegrating tablets (MDTs) of losartan Potassium. Conventional tablets cannot be taken without water. Tablet or capsule cannot be taken by the patient without using water or any other liquid. The problem in swallowing, dysphagia, is common is patient of all age groups, especially pediatrics and geriatrics. Fast dissolving Tablets are swallowed and can get dissolve in the saliva without water and these are true fast dissolving tablets. Rest contain agents to prepare the rate of tablet disintegration in the oral cavity, and is referred to as fast disintegrating tablets because they make take at least a minute to completely disintegrated. Losartan potassium is an active medicine of non-peptidergic angiotensin II receptor antagonist. It is the first new class of drugs to be introduced for clinical use in hypertension. In patients with mild to moderate hypertension, losartan potassium 50 to 100mg once used daily as monotherapy lowers blood pressure to a similar degree to enalapril, atenolol and felodipine extended release (ER). However, with its novel mechanism of action, good efficacy and favorable tolerability profile, losartan potassium is well placed to claim a prominent position in the management of patients with essential hypertension in the future.
Authors and Affiliations
Pankaj Bhatt
Keywords
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