Multiple electrode aggregometry – only for cardiologists
Journal Title: Annales Academiae Medicae Silesiensis - Year 2016, Vol 70, Issue
Abstract
Multiple electrode aggregometry is one of the newest technologies in platelet function monitoring. The idea of this assay is based on whole blood impedance aggregometry measurements. The main advantages of this device are rapid and easy use, no necessity of sample pre-processing or requiring a specialized laboratory. These features allow one to include this methodology in point-of-care testing methods that can be performed at the patient bedside. Five different pathways of platelet activation can be investigated by adding specific reaction agonists. Antiplatelet drugs, such as acetylsalicylic acid or clopidogrel, inhibit arachidonic acid-dependent and adenosine diphosphate-dependent pathways of platelet activation. Individual patient response to these drugs can be estimated using multiple electrode aggregometry. The identification of low-responders may result in reducing thrombosis events in this group and make antiplatelet treatment more effective. Furthermore, it is supposed to be a reliable method of estimating the risk of perioperative bleeding in adults undergoing cardiac surgery. Other potential clinical applications for this technology are being found. Many studies report its use in determining prognosis in severe sepsis, detecting heparin-induced thrombocytopenia and diagnosing von Willebrand disease. Although multiple electrode aggregometry seems to have great diagnostic potential, more tests need to be performed before it becomes standard hospital equipment.
Authors and Affiliations
Adrianna Spałek, Michał Żorniak, Tadeusz F. Krzemiński
Keywords
Related Articles
- EP ID EP367442
- DOI 10.18794/aams/59505
- Views 104
- Downloads 0
Effect of PNF-therapy on recovery in patients after ischemic stroke located in left hemisphere in acute rehabilitation
AIM The aim of the work was to examine the influence of PNF-therapy (proprioceptive neuromuscular facilitation therapy) based rehabilitation on the improvement process of motor impairment in patients after ischemic strok...
Rokowanie chorych z wczesną miażdżycą tętnic wieńcowych w 4-letniej obserwacji
WSTĘP: Choroby układu krążenia, powodowane głównie miażdżycą i jej powikłaniami, są najczęstszą przyczyną chorobowości i śmiertelności na świecie. Miażdżyca rozwija się już we wczesnym wieku dziecięcym, a u około 50% mło...
Aktywność fizyczna w okresie ciąży i jej wpływ na czas trwania porodu oraz połogu
CEL PRACY: Celem pracy była ocena poziomu aktywności fizycznej kobiet przed i w trakcie ciąży oraz ustalenie, czy aktywność fizyczna wpływa na trwanie porodu i okres połogu. MATERIAŁ I METODY: Badania przeprowadzono na...
Implementation of vitamins D and K supply guidelines at various times since their introduction in infant population of urban agglomeration in Upper Silesia
INTRODUCTION The supplementation of some vitamins is set by specific guidelines. They include the supply of vitamin D from the neonatal period to old age (2009) and vitamin K to neonates and infants (2007). The aim of th...
Limbal epithelial stem cells in regeneration of corneal epithelium – clinical and molecular aspects
Limbal epithelial stem cells (LESC) are located at the junction between the cornea and sclera. Their function is to reconstruc-ting and replace damaged or dysfunctional cells. In this paper information on the characteris...