Mutation Prone Point In Thyrotropin Releasing Hormone Receptor
Journal Title: Journal of Neurological Sciences-Turkish - Year 2007, Vol 24, Issue 4
Abstract
Background: Thyrotropin-releasing hormone (TRH) has an important role in the regulation of energy homeostasis. Pathological alterations of TRH receptor (TRHR) structure and function are an important cause of genetic neuroendocrine defect. Mutation within TRHR can be seen. Presently, prediction of protein nanostructure and function is a great challenge in the proteomics and structural genomics era. Methods: To identify the point vulnerable to mutate is a new trend to expand the knowledge on disorders in genomic and proteomic level of diseases. Here, the author performed a bioinformatics analysis to study the determine positions that tend to comply peptide motifs in the amino acid sequence of TRHR. To identify the weak linkage in TRHR, a new bioinformatics tool namely GlobPlot was used. Results: According to this work, the positions prone to mutation are identified. Conclusion: This means that TRHR is a very high genetic unstable molecule. Thousands types of mutations can be expected. Of interest, only a few sense mutations is mentioned in clinic. Therefore, it might be many occulted sensed mutation to be detected.
Authors and Affiliations
Viroj WIWANITKIT
Keywords
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