Myelodysplastic syndromes – current diagnostic approach, classification and treatment Part I: Diagnosis, classification an prognostic stratification of myelodysplastic syndromes
Journal Title: Postępy Nauk Medycznych - Year 2011, Vol 24, Issue 6
Abstract
Myelodysplastic syndromes are a group of acquired heterogeneous clonal disorders of hematopoietic stem cell characterized by ineffective hematopoiesis, refractory cytopenias and an increased risk of transformation into acute myeloid leukemia. This work presents recent views on diagnostic work-up, classification and prognostic stratification of myelodysplastic syndromes. In order to establish diagnosis, as well as to identify prognostic factors blood morphology tests including peripheral blood smear assessment with light microscope, and cytological, histopathological, cytochemical and cytogenetic marrow examinations are required. Precise diagnostic criteria according to World Health Organization (WHO) guidelines and risk stratification based on the International Prognostic System Score (IPSS) and WHO based Prognostic Scoring System (WPSS) are presented.
Authors and Affiliations
Dariusz Kata, Sławomira Kyrcz-Krzemień
Keywords
Related Articles
- EP ID EP54204
- DOI -
- Views 132
- Downloads 0
Nagłe zatrzymaniu krążenia w okresie przedszpitalnym – przyczyny, rokowanie, perspektywy leczenia - doniesienie wstępne
91 pacjentów po nagłym zatrzymaniu krążenia ( NZK) w okresie przedszpitalnym było leczonych w Pododdziale Intensywnej Opieki Kardiologicznej Szpitala Bielańskiego w latach 2004-2009. Spośród ocenianych chorych, 62 % zmar...
Comparison of identification methods of vancomycin-resistant enterococci in MALDI-TOF MS, Vitek 2 and API 20 STREP
Introduction. From the clinical point of view, differentiation of the following species in the genus Enterococcus is the most important: E. faecium and E. faecalis (responsible for over 90% of all enterococcal infections...
Modern methods of therapy of hard-to-heal post-operative wounds in obstetrics and gynecology – analysis of applicability and effectiveness of use
Impaired healing of post-operative wound constitutes a significant medical problem worldwide. Infected, chronic and hard-to-heal wounds leading to dehiscence of the surgical site layers expose patient to the development...
The imaging of sterno-clavicular joints in SAPHO syndrome
SAPHO syndrome is seronegative spondyloarthropathy characterized by dermatological symptoms such as pulstulosis palmo-plantaris and acne, and osteoarticular symptoms.<br>Diagnostic procedures of SAPHO syndr...
Torbielowatość kłębuszków nerkowych z towarzyszącym włóknieniem śródmiąższu nerek u pacjentki z nawrotową ich niewydolnością
Przedstawiamy przypadek 23-letniej kobiety, u której w biopsji nerki, wykonanej z powodu narastającej niewydolności nerek, uwidoczniono cechy torbielowatości kłębuszków nerkowych z towarzyszącym miernie rozległym włóknie...