Myelofibrosis Associated, with Rickets, is it Hyperparathyroidism the Triggering Agent or Vitamin D and Hypocalcemia or Hypophosphatemia?
Journal Title: International Journal of Clinical Endocrinology and Metabolism - Year 2016, Vol 2, Issue 1
Abstract
Anemia due to iron deficiency is commonly associated with rickets, but rarely myelofibrosis was seen in infants with rickets in the hypocalcaemic phase. The aim of this review is to elucidate the mechanism of development of myelofibrosis in rickets. We reviewed the literature in PubMed with keywords myelofibrosis, hypocalcemia and anemia. The cases diagnosed as myelofibrosis in infants with evidence of rickets were studied. Hypocalcemia as it occurred in all the cases reported, it suggests that an association exists between myelofibrosis and hypocalcemia possibly as a consequence of a disturbed vitamin D metabolism. We could not find another evidence to support a direct relation between low calcium per se and myelofibrosis. Vitamin D with its multiple metabolites and whose levels in our sunny communities are getting lower and lower with more associated diseases being discovered still needs to be considered.
Authors and Affiliations
Elidrissy Abdelwahab T H
Keywords
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- EP ID EP542075
- DOI 10.17352/ijcem.000017
- Views 52
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