Myorelaxant And Calcium Channel Blocker Properties Of An Aqueous Extract Of Solanum Torvum (Solanaceae) On Isolated Rabbit’s Intestinal Smooth Muscle
Journal Title: American journal of Engineering Research - Year 2018, Vol 7, Issue 7
Abstract
The aqueous extract of Solanum torvum (EASt), at concentrations ranging from 10-1 to 6.10-1 mg/ml, caused a dose-dependent decrease in the amplitude of spontaneous rhythmic contractions and basal tone of isolated rabbit’s duodenum. This myorelaxation was dose dependently antagonized by propranolol (10-4 to 10-2 mg/ml). In a physiological solution devoid of calcium, EASt completely inhibits intestinal rhythmic contractions and causes a decrease in basal tone. A completeinhibition of intestinal rhythmic contractions was also observed by adding EASt to a 0 Ca2+physiological solution+ EDTA. However, in a 0 Ca 2+ solution+ EGTA, the crude extract of Solanum torvum did not exhibit any effect. EASt therefore has myorelaxant properties and might act by promoting the decrease of intracellular calcium concentration in the intestinal smooth muscleby stimulating adrenergic receptors and blocking the intracellular and extracellular calcium channels. Detection of phytocompounds such as tannins and flavonoidsin the aqueous extract of Solanum torvum through phytochemical screening which antispasmodic, anti-diarrheal and myorelaxant effects have been demonstrated by other authors could justify its myorelaxant properties and traditional use as an anti-diarrheal.
Authors and Affiliations
N’guessan K. J. *,, Abo K. J-C. , Mea A. , Irié Bi J. S. ,, Kahou Bi G. P
Keywords
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