N-Terminal Pro-Brain Natriuretic Peptide as a Predictor of Complication and Mortality in Acute St Segment Elevation Myocardial Infarction
Journal Title: International Journal of Contemporary Medical Research - Year 2017, Vol 4, Issue 5
Abstract
Introduction: Coronary artery disease and its end result, myocardial infarction continues to be a significant cause of mortality and morbidity in the world. Over the past 50 years, it has become clear that the cascade of thrombotic events following atherosclerotic plaque rupture causes occlusion of the coronary artery, interrupting blood supply and oxygen to myocardium thus resulting in infarction. So Study aimed to assess the relationship between N-terminal pro-Brain Natriuretic Peptide levels on admission in ST elevation myocardial infarction (STEMI) and its short term complications Material and Methods: A total of 40 patients, who present with acute ST elevation myocardial infarction within 12 hrs to Rajendra Institute of Medical Sciences, were included in this study. NT-ProBNP and other routine cardiac evaluations at the time of admission were determined. The patients were followed over a period of 7 days for development of various short term complications of acute MI. Results: Among the complications arrhythmias comprised the majority with 22.5% (9 subjects). 5 patients (12.5%) succumbed to death. NT-proBNP levels in the full cohort ranged from 246 to 3000 p g/ ml. The mean levels were 1585.6 5±99 9.1 33 p g/ ml with the median NT-proBNP as 1483.50 pg/ ml. NT-proBNP cutoff of 1691.50 pg/ml has 100% sensitivity and 88.9% specificity in predicting the occurrence of complications in STEMI. Conclusion: NT-proBNP is a strong predictor of short term outcome in AMI, including death
Authors and Affiliations
Mrinal Kunj, Bindey Kumar, Anshu Kumar
Keywords
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