Natural Polymer from Sesamum radiatum as an Emulsifier and Stabilizer in Fabrication of Macroemulsions
Journal Title: Journal of Pharmaceutical Research International - Year 2015, Vol 8, Issue 4
Abstract
Aim: Sesamum gum was extracted from the leaves of Sesamum radiatum and evaluated as emulsifier or stabilizer in coarse emulsions. Methods: The emulsion systems were assessed by monitoring of emulsion density, viscosity, globule size, and by evaluating the effects of temperature and salt over a four week period. Results: It was observed that the known 4:2:1 ratio did not form emulsions when sesamum was used but other ratios such as 2:4:1, 2:4:0.5, 2:4:0.25 and 2:4:0.125 formed emulsions. The emulsions were however, unstable. When sesamum gum was used as a stabilizing agent (0.4%/v – 2.0%/v), and acacia (7.5%/v) as an emulsifying agent, stable emulsions were formed. At the end of four weeks, the emulsion systems exhibited lower globule sizes (1.68-1.95 µm) than the emulsion systems containing acacia alone (3.95 µm) as emulsifier. The emulsions creamed or cracked when exposed to temperatures of about 40°C over 4 weeks. They were however stable even in the presence of salt of 1.0%/v concentration. Conclusion: The presence of sesamum as a stabilizer influenced the globule size and size distribution, the viscosity and consequently the stability of the emulsions. The study suggests that sesamum gum possesses the desirable properties of emulsifier/stabilizer in emulsions.
Authors and Affiliations
Ndidi C. Ngwuluka, Edith O. Ugwuagbo, Elijah I. Nep, Patrick O. Olorunfemi, Patricia O. Odumosu, Nelson A. Ochekpe
Keywords
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- EP ID EP344455
- DOI 10.9734/BJPR/2015/19729
- Views 93
- Downloads 0
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