Altered Membrane Potential and Electrolyte in Sickle Cell Anemia
Journal Title: Journal of Krishna Institute of Medical Sciences University - Year 2014, Vol 3, Issue 1
Abstract
Aim: This study has been to evaluate the level of membranepotential and electrolyte in sickle cell diseasepatients. Material and methods: 100 sickle cell patientsin steady state ages 5 to 30 years attending GeneralHospital Owerri were used in the study while 100normal subjects (HbAA) were used as control. Also30 HbSS in crisis have been involved. Results: Theresults obtained showed that the level of membranepotential was significantly lower in sickle cell anemiaas compared to the controls. Also, the level of the electrolytewas found significantly decreased in HbSS whencompared with HbAA at P<0.05. Conclusion: Themembrane potential translates to energy which meansthat there is less energy in sickle cell disease which islinked to electrolyte imbalance. Hence people withsickle disease should be monitored closely for their electrolytesto avoid crisis.
Authors and Affiliations
JK Nnodim , SC Meludu , CE Dioka , C Onah , UJ Chilaka , PC Obi
Keywords
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