Antidepressant effect and categorization of Inhibitory activity of monoamine oxidase type A and B of ethanolic extract of seeds of Trigonella foenum graecum Linn
Journal Title: Pakistan Journal of Pharmaceutical Sciences - Year 2014, Vol 27, Issue 5
Abstract
Trigonella foenum- graecum Linn (Fabaceae) is an annual aromatic herb and no wit is cultivated globally like in Pakistan, Egypt, India, Middle East etc. Traditionally it was used in anorexia, as febrifuge, to soothe gastritis and gastric ulcers, as a galactagogue and as condiment, hypoglycemic agent and employed in various as nervous disorders. The study aimed to investigate the antidepressant effect of ethanolic extract of seeds of Trigonella foenum graecum and underlying mechanism of action. For assessment of antidepressant activity Forced Swimming Test (FST), Tail Suspension Test (TST), Monoamine (MAO) Assay and Locomotor Activity Test were studied. Acute toxicity, Rota Rod and Grip Strength Tests were also performed. The significant declining in immobility time as compared to control was shown in Forced swimming test as compared to tail suspension test. Considerable change was not found in open field test (OFT). EtOH extract of seeds of fenugreek represent maximum significant reduction which was 30 and 24.65%in MAO- A and B activity respectively in the rat’s whole brain as compared to control animals in Monoamine oxidase (MAO) assay. All tested doses were found ineffective in impairment of muscle coordination in Rota rod and in grip strength related to muscle relaxant property. According to experimental findings it is revealed that ethanolic extract of seeds of Trigonella foenum graecum showed antidepressant effect by inhibiting the activity of MAO-A and B.
Authors and Affiliations
Raheela Khursheed , Ghazala H Rizwani , Viqar Sultana , Maryam Ahmed , Arfa Kamil
Keywords
Related Articles
- EP ID EP94545
- DOI -
- Views 88
- Downloads 0
Bacopa monnieri: An evaluation of antihyperglycemic and antinociceptive potential of methanolic extract of whole plants
Antihyperglycemic and antinociceptive activity studies were carried out with methanolic extract of whole plants of Bacopa monnieri, respectively, through oral glucose tolerance test and gastric pain model induced b...
Evaluation of carrier added and no carrier added 90Y-EDTMP as bone seeking therapeutic radiopharmaceutical
The optimum conditions to label ethylenediaminetetramethylene phosphonate (EDTMP) compound with 90y as a potential candidate for bone metastases therapy were investigated. Yttrium-90 is a pure β-emitter and can be...
A cardiac electrical activity model based on a cellular automata system in comparison with neural network model
Cardiac Electrical Activity is commonly distributed into three dimensions of Cardiac Tissue (Myocardium) and evolves with duration of time. The indicator of heart diseases can occur randomly at any time of a day. H...
Report: Prevalence of shigellosis in three different areas of Karachi
Abstract: Shigellosis is communicated when the pathogen is swallowed down through the factors like stool or polluted hands with dust. Inappropriate hygienic conditions may reach such clinical manifestations. Shigel...
Regulation of ROS defense system by Hybanthus enneaspermus in CCl4 induce cardiac damage
The purpose of this study is to regulate the ROS (Reactive oxygen species) defense system in cardiac damage induced by CCl4 (Carbon tetra chloride) in rats using Hybanthus enneaspermus. Administration of CCl4 induc...