Antioxidant and cardio protective effect of palm oil leaves extract (standardized ethanolic fraction) in rats’ model of saturated fats induced metabolic disorders
Journal Title: Pakistan Journal of Pharmaceutical Sciences - Year 2014, Vol 27, Issue 1
Abstract
Recently, it is suggested to use POLE (palm oil leaf extract) as a nutraceutical health product in food industry due to its newly discovered content of polyphenols and antioxidant vitamins. In the experiment, the antioxidant and anti-lipid-peroxidation activities of the extract were confirmed using; DPPH (1-diphenyl-2-picryl-hydrazil) radical scavenging activity, ferric ion induced lipid peroxidation inhibition, reducing power and hydrogen peroxide scavenging activity assays. The cardio-protective activity was studied in vivo using a model of metabolic syndrome induced by high fat diet. Lipid profile, obesity indices, renal tubular handling of water and electrolytes, blood pressure and arterial stiffness were measured at the end of the treatment period. Sprague Dawley rats weighing 150-200 g were divided into six groups, viz; group C; was treated as a negative control and fed with standard rodents chow, group H; was treated as a positive control and fed with an experimental diet enriched with saturated free fatty acids for 8 weeks, groups HP0.5, HP1 and HP2 which were fed with 0.5,1 and 2 g/kg (body weight) /day of POLE orally during the last 24 days of the high fat diet feeding period and group P; fed with highest dose of POLE. Results revealed that POLE possesses a cardio-protective effect which is ascribed to its content of polyphenols
Authors and Affiliations
Zaid O Ibraheem , Munnavar Satar , Nor A. Abdullah , Hassaan Rathore
Keywords
Related Articles
- EP ID EP115501
- DOI -
- Views 89
- Downloads 0
Synthesis, characterization and biological evaluation of tryptamine based benzamide derivatives Kiran
Benzamides and tryptamine are biologically significant compounds, therefore, various benzamide analogous of tryptamine have been efficiently synthesized using tryptamine and different benzoyl chlorides, in order t...
Availability of antidotes and key emergency drugs in tertiary care hospitals of Punjab and assessment of the knowledge of health care professionals in the management of poisoning cases
This study was conducted to evaluate the availability of antidotes / key emergency drugs in tertiary care hospitals of the Punjab province, and to assess the knowledge of health care professionals in the stocking a...
Bone Marrow Stromal Cell (BMSC) and skeletal aging: Role of telomerase enzyme
Abstract: Telomere shortening and telomerase deficiency have been linked with several age related degenerative diseases. Moreover, degenerative changes in various tissues/organs have been attributed to derangement...
Pluronic F127 as a drug vehicle used in chick embryo chorioallantoic membrane shell-less model
The developing vascular network is grown on the surface of chick embryo chorioallantoic membrane (CAM), so CAM is widely used as an in vivo model to study the angiogenesis. Because the CAM is hindered or wrinkled b...
Hepatic histological alterations and biochemical changes induced by sildenafil overdoses
Sildenafil is used for the treatment of erectile dysfunction and is helping millions of men around the world to achieve and maintain a long lasting erection. Fifty healthy male rabbits (Oryctolagus cuniculus) were...