CLINICAL CO RELATION BETWEEN ARTERIAL VERSUS VENOUS AMMONIA LEVELS IN HEPATIC ENCEPHLOPATHY IN CIRRHOSIS OF LIVER
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2014, Vol 3, Issue 19
Abstract
[b]INTRODUCTION:[/b] Hepatic encephalopathy is a reversible neuropsychiatry state that complicates liver disease. Pathogenesis of Hepatic Encephalopathy in chronic liver is function is widely accepted to be due to failure of hepatic clearance of toxins products from gut exact toxin involved remains controversial but ammonia is thought to be an important factor. Ammonia levels help both in diagnosis and serve as a guide in treatment. Diagnosis of Hepatic Encephalopathy can be done based on clinical criteria and the severity of Hepatic Encephalopathy can be graded by West Haven Criteria. This criterion is the simplest grading of Hepatic Encephalopathy based on clinical findings. [b]AIMS AND OBJECTIVES:[/b] To correlate between Ammonia levels and clinical severity of Hepatic Encephalopathy in Cirrhosis of liver and correlate between Arterial versus venous ammonia levels with severity of Hepatic Encephalopathy. [b]RESULTS: [/b]Male patients had higher incidence than females. Severity of hepatic encephalopathy was graded by West Haven grading. Arterial total ammonia and venous ammonia was correlated with the clinical severity of HE. Of the 50 patients 3 had grade 1, 18 had grade 2, 22 had grade 3 and 7 had grade 4. Arterial and venous ammonia levels co related with severity of HE. The highest level of arterial ammonia was seen in grade 3 and grade 4.It was seen that other lab parameters also increased with severity of HE. But were not significant. Serum albumin was inversely co related with severity of HE. [b]CONCLUSIONS:[/b] Arterial total ammonia correlated better with the severity of Hepatic Encephalopathy as compared to venous ammonia levels. Venous total ammonia did not correlate with severity of Hepatic Encephalopathy and with arterial ammonia levels.
Authors and Affiliations
Manjunath R, Nagesh H. N, Vaishali Bhardwaj
Keywords
Related Articles
- EP ID EP101050
- DOI 10.14260/jemds/2014/2594
- Views 59
- Downloads 0
MICROALBUMINURIA IN NON-PROTEINURIC DIABETIC PATIENTS AND ITS CORRELATION WITH DIABETIC RETINOPATHY AND NEUROPATHY- A CROSS-SECTIONAL STUDY IN A TERTIARY CARE HOSPITAL
BACKGROUND Diabetes is a stage of persistent hyperglycaemia due to absolute or relative deficiency of insulin. Microalbuminuria is often the first sign of renal dysfunction in diabetes. Microalbuminuria is defined as the...
180 DEGREES TORSION OF THE TERM GRAVID UTERUS –A CASE REPORT ON THIS RARE OBSTETRIC EMERGENCY
Uterine torsion is defined as a rotation of the uterus of more than 45 degrees on its long axis. It is an unusual complication of pregnancy and for most obstetricians it probably represents a ‘once in a lifetim...
CLINICAL STUDY OF ENDOSCOPIC FINDINGS IN PATIENTS PRESENTING WITH UPPER GI SYMPTOMS
BACKGROUND Fibreoptic endoscopy has become the reliable, quick and inexpensive modality of investigation. Upper Gastrointestinal disorders are on rise in today’s era due to change in lifestyle, food and habits. Endoscopy...
TUBERCULOSIS OF THE BREAST- A SURGICAL PERSPECTIVE
BACKGROUND Tuberculosis of the breast is a rare entity. Incidence of breast tuberculosis in Western World is < 0.1% of the breast lesions examined histopathologically. The overall incidence in developing countries is app...
ASSESSMENT OF DISINFECTION AND CLEANING VALIDATION IN CENTRAL LABORATORY, MBS HOSPITAL, KOTA
BACKGROUND Many outbreaks are still caused by contaminated surfaces, and the technical drawbacks of liquid disinfectants may be partially to blame for the high facility-acquired infection rates in health care. These outb...