Comparative study of medicinal plant (azadirachta indica) with diclofenac on anti-inflammatory activity
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2015, Vol 5, Issue 3
Abstract
The inflammation is a biologically action on living tissue heomeostasis. Acute inflammation causes by bacterial infection, tissue necrosis and sign of inflammation are heat (calor), pain (dolor), redness(rubor), swelling (tumour) and loss of function (functio laesa). The inflammation produces by prostaglandins, serotonin, and cytokines. NSAIDs are used in treatment of Inflammation. The Azadirachta indica also produce anti inflammatory activity. The ethanolic extract (100mg/kg) of leave of neem plant are showed anti inflammatory activity in albino rats. The Diclofenac(5mg/kg) standard drug used in the experimental degion. The phlogistic agent (0.1 ml of 1.0% carrageenan) was used for induce inflammation in subplanter region of hind paw in wistar rats. The Diclofenac showed best anti inflammatory activity as compared as to ethanolic leaves extract of neem. The diclofenac drug is more effective as compared to neem leave extract.
Authors and Affiliations
Rajesh Asija1 , Pankaj Vyas2 , Rajesh Prajapat3
Keywords
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