COMPARATIVE STUDY OF THE INDUCTION OF LABOUR WITH INTRAVAGINAL MISOPROSTOL AND INTRACERVICAL DINOPROSTONE GEL
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2016, Vol 5, Issue 21
Abstract
OBJECTIVES To compare the efficacy of labour with Dinoprostone gel and Misoprostol with respect to induction delivery interval, type of delivery and cost effectiveness. METHODS 100 patients admitted to labour ward of OBG Department of Katuri Medical College and Hospital with indications for induction of labour and unfavourable cervices randomly assigned to receive either intravaginal Misoprostol or intracervical Dinoprostone gel between August 2012 and August 2013; 50 patients received 25 µg of intravaginal Misoprostol every 4 hours, maximum of 6 doses; 50 patients received 0.5 mg Dinoprostone gel intracervically every 6 hours, maximum of 3 doses as needed. RESULTS In Dinoprostone group, the mean induction delivery interval was 15.25±3.14 hrs. In the Misoprostol group, the mean induction delivery interval was 11.43±2.17 hrs; 72% required Oxytocin augmentation in the Dinoprostone group compared to 38% in Misoprostol group which is statistically significant (P<0.05); 78% of patients had vaginal delivery in Dinoprostone group and 90% of patients had vaginal delivery in Misoprostol group which is statistically significant (P<0.05). There was 10% incidence of NICU admission in both groups. CONCLUSION Misoprostol and Dinoprostone are safe and effective drugs for cervical ripening and labour induction. Misoprostol is more cost effective when compared to Dinoprostone. Misoprostol is stable at room temperature and does not need refrigeration, whereas Dinoprostone required refrigeration. Induction delivery interval, requirement of Oxytocin augmentation is less in Misoprostol group when compared to Dinoprostone group. Vaginal delivery rate is high in Misoprostol group when compared to Dinoprostone. These findings suggest that Misoprostol is safe, effective and inexpensive agents for cervical ripening and labour induction.
Authors and Affiliations
Priya Alaparthi , Katta
Keywords
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- EP ID EP112550
- DOI 10.14260/jemds/2016/260
- Views 97
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