Detection of Insulin-Like Protein and Some Active Compounds in Bauhinia Variegata Linn. Leaf Ethanolic Extracts and the Effect in Reducing Blood Glucose Levels in Mice
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2014, Vol 4, Issue 3
Abstract
The study aims to detect the insulin-like protein and determine the active compounds in Bauhinia variegata L. leaves ethanolic extracts that help in reducing the blood glucose levels for white albino mice. The chemical detection of leaves ethanolic extract revealed the presence of tannins, terpenes, steroids, and flavonoids as active compounds. High performance liquid chromatography (HPLC) analysis method, using C18 column resulted in presence of insulin-like protein in the leaves extracts. Results showed significant reduction of blood glucose levels after 3 days of the treatment, and high reduction obtained after 6, 9, 12 days as compared with the human swine insulin used as a control. It was concluded that the crude ethanolic extracts and the partial purified insulin of B. variegata was used to examine the existence of insulin-like protein in this plant. This study is an attempt to report plant insulin that may be useful to the student in the field of pharmacology and therapeutics to develop alternative medicine to cure diabetes in human.
Authors and Affiliations
Khaleel Ibrahim Rashid
Keywords
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