DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRIC METHOD FOR QUANTITATIVE ESTIMATION OF CEFTAROLINE FOSAMIL IN BULK AND INJECTION FORM
Journal Title: Int J of Pharm Res & Analy - Year 2012, Vol 2, Issue 2
Abstract
Two simple, sensitive, specific, spectrophotometric methods have been developed for the determination of ceftaroline fosamil in bulk and Injection forms. The λmax of ceftaroline fosamil was found to be 245.2 nm in distilled water. The zero order UV Spectrophotometric method exhibits high sensitivity, with linearity and obeys beer’s law in the range of 2 – 10 μg/mL. The limit of detection and quantification were found to be 0.231 μg/mL and 0.7019 μg/mL respectively. While area under curve for zero order spectrum of ceftaroline fosamil was measured from 235 – 255 nm which obeys Beer’s law in the concentration range of 2 – 10 μg/mL. These methods were fully validated according to ICH guidelines. The LOD and LOQ were found to be 0.223μg/mL and 0.669 μg/m, respectivelyL. Hence it could be concluded that the proposed methods would be suitable for the analysis of ceftaroline fosamil in bulk and pharmaceutical preparations
Authors and Affiliations
A. Suneetha , China Venkanna , S. Kathirvel
Keywords
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