SPECTROPHOTOMETRIC METHOD FOR DETERMINATION OF Fe(II) AND Zn(II) IN MULTIVITAMIN SOFT GEL CAPSULE
Journal Title: Int J of Pharm Res & Analy - Year 2012, Vol 2, Issue 2
Abstract
The present work describes novel spectrophotometric method for the determination of Fe(II) and Zn(II) in multivitamin soft gel formulation. The method is based on formation of coloured complexes of Fe(II) and Zn(II) with 2,2’-Bipyridyl and Dithizone respectively. Fe(II) forms deep red colored chromogen with 2,2’-Bipyridyl having maximum absorbance at 510nm and Zn(II) complexes with dithizone to develop cherry red color having maximum absorbance at 525nm. Beer’s law was obeyed in the range of 10 – 35 μg/ml for Fe(II) and 2 – 12 μg/ml for Zn(II). The detection limits were 1.85 μg/ml and 0.11 μg/ml for Fe(II) and Zn(II) respectively. The RSD values were, in all instances less than 2.0%. No interference was observed form common pharmaceutical adjuvants and both Fe(II) and Zn(II) were successfully determined in their dosage form.
Authors and Affiliations
Pratik S , Vandana B. Patel
Keywords
Related Articles
- EP ID EP126776
- DOI -
- Views 139
- Downloads 0
A REVIEW ON LASER-INDUCED BREAKDOWN SPECTROSCOPY
Laser-induced breakdown spectroscopy (LIBS) is a type of atomic emission spectroscopy which uses a highly energeticlaser pulse as the excitation source. The laser is focused to form a plasma, which atomizes and excites s...
BIOANALYTICAL METHOD VALIDATION – A REVIEW
The present review should extensively be discussed on an international level to reach a consensus on the extent of validation experiments and on acceptance criteria for validation parameters of bioanalytical method...
MICROSPONGES: A NOVEL DRUG DELIVERY SYSTEM FOR CONTROLLED DELIVERY OF TOPICAL DRUGS
Even though possess several advantages topical formulations have some drawbacks such as the need to contain high concentrations of active agents for effective therapy due to the low efficiency of delivery system, r...
SCREENING OF WOUND HEALING ACTIVITY OF BARK OF ALEURITES MOLUCCANA L.
Aleurites moluccana L. is used in folklore medicine in fomenting, sealing of secondary infection, healing of wounds and skin eruptions. There was no scientific evidence justifying the use of bark of Aleurites moluc...
ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF MULTICOMPONENTS IN BULK AND TABLET DOSAGE FORM
A simple, accurate, precise, and sensitive and a highly selective UV-spectrophotometric method were developed for the simultaneous estimation of atorvastatin calcium and pyridoxine hydrochloride at a maximum wavele...