ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF MULTICOMPONENTS IN BULK AND TABLET DOSAGE FORM
Journal Title: Int J of Pharm Res & Analy - Year 2014, Vol 4, Issue 2
Abstract
A simple, accurate, precise, and sensitive and a highly selective UV-spectrophotometric method were developed for the simultaneous estimation of atorvastatin calcium and pyridoxine hydrochloride at a maximum wavelength of 259 nm and 288 nm respectively. The method was found to be linear in the range of 2 – 10 μg/ml with mean recovery in the range of 98% -102% for atorvastatin calcium & pyridoxine hydrochloride. The developed method was validated according to ICH guidelines and it was found to be accurate and precise, thus the proposed method can be successfully applied for simultaneous determination of atorvastatin calcium & pyridoxine hydrochloride in routine analysis work.
Authors and Affiliations
M. J. Jamadar , M. S. Kondawar , K. A. Wadkar
Keywords
Related Articles
- EP ID EP157990
- DOI -
- Views 109
- Downloads 0
ANTIOXIDANT DEFENSE ENZYMES ACTIVITY IN HYPOBARIC HYPOXIA SUSCEPTIBLE AND TOLERANT SPRAGUE DAWLEY RATS
Antioxidant enzymes are known defense molecules, which eliminate reactive oxygen species (ROS) and free radicals that damage useful enzymes in the cell under various stress conditions. Significant efforts have been made...
SEASONAL WATER QUALITY ASSESSMENT OF SURFACE WATER IN DURG REGION
An investigation was undertaken to determine the Quality of surface water of Shivnath River & ponds in durg and rajnandgaon region”. The study assessed the evolution of water quality in Surface of Durg and Rajn...
ASSESSMENT OF HEAVY METAL CONTAMINATION IN PLASTIC MUGS, FREQUENTLY USED AT LOCAL RESTAURANTS OF DIFFERENT DISTRICTS OF U.P. INDIA
A total number of 42 mugs manufactured from plastics (locally made) were purchased and analyzed to determine the level of zinc, nickel, iron and cadmium. All samples were digested with concentrated nitric acid (HNO...
DEVELOPMENT AND VALIDATION OF NEW RP-HPLC METHOD FOR PACLITAXEL IN BULK AND ITS PHARMACEUTICAL DOSAGE FORM
A simple, precise, rapid and accurate reverse phase HPLC method has been developed for the determination of Paclitaxel in bulk and its pharmaceutical dosage form. An enable C18G, 250mm, X4.6mm i.d, 5μm particle siz...
DEVELOPMENT AND VALIDATION OF NEW SPECTROPHOTOMETRIC METHODS FOR THE QUANTITATIVE ESTIMATION OF SILODOSIN IN BULK DRUG AND PHARMACEUTICAL FORMULATIONS
Three simple, sensitive, accurate and rapid spectrophotometric methods A, B and C have been developed for the quantitative estimation of Silodosin in bulk drug and also pharmaceutical formulations. Method A is a UV...