EVALUATION OF OXIDATIVE STRESS AND ANTIOXIDANT STATUS IN DIABETIC RETINOPATHY CASES
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2013, Vol 2, Issue 12
Abstract
[b] CONTEXT[/b]: Diabetes is the most rapidly growing chronic metabolic disorder in the world. In diabetes mellitus, the oxidative stress resulting from enhanced free radical formation and a defect in antioxidant defenses has been implicated in the pathogenesis of diabetes and its complications like neuropathy, retinopathy, nephropathy, etc. [b]AIMS[/b]: The objective of the study is to know the oxidative stress by estimating serum malondialdehyde (MDA) levels and antioxidant status by measuring serum vitamin levels, and to know the correlation between MDA and other parameters in cases of diabetic retinopathy. [b]SETTINGS AND DESIGN[/b]: Present study involved 100 participants of which 50 were diagnosed as having diabetic retinopathy and 50 were age and sex matched healthy controls. The degree of lipid peroxidation in terms of serum malondialdehyde (MDA) along with antioxidant defenses, vitamin A, vitamin C and vitamin E levels were estimated in cases and controls. Fasting blood sugar (FBS), post prandial blood sugar (PPBS) and HbA1c were also estimated in both cases and controls. [b]STATISTICAL[/b] [b]ANALYSIS USED[/b]: Student t test (two tailed, independent) has been used to find the significance of study parameters on continuous scale between two groups (Inter group analysis) on metric parameters. Pearson correlation between MDA and other parameters was performed to assess the relationship in each group. [b]RESULTS[/b]: In diabetic retinopathy patients statistically highly significant increase in levels of FBS, PPBS and HbA1c (P<0.001) was observed when compared to controls. The levels of serum MDA (P<0.001) was increased significantly in diabetic retinopathy cases as compared to controls. The levels of serum vitamin A, vitamin C and vitamin E were significantly (P<0.001) reduced in all diabetic retinopathy patients. A positive correlation was observed between MDA and FBS, PPBS, HbA1c. A negative correlation was found between MDA and vitamin A and vitamin C. [b]CONCLUSIONS[/b]: The present study concludes that excessive peroxidation damage and antioxidant deficiency occurs in diabetic retinopathy. Further trials regarding the therapeutic measures to control lipid peroxidation and to increase the antioxidant levels are warranted for effective control of diabetic complications.
Authors and Affiliations
Maithri C. M, Aliya Nusrath, Rajeshwari A
Keywords
Related Articles
- EP ID EP148625
- DOI 10.14260/jemds/476
- Views 78
- Downloads 0
TO COMPARE THE ANALGESIC EFFICACY OF 0.25% BUPIVACAINE AND 0.25% ROPIVACAINE IN TAP BLOCK AS A PART OF A MULTIMODAL ANALGESIA REGIMEN FOR POST CAESAREAN DELIVERY PAIN MANAGEMENT
BACKGROUND Women having a caesarean delivery present a unique set of challenges to the Anaesthetist postoperatively. They need to be alert, comfortable and ambulant in order to care for their newborn.[1] As part of a mul...
CHANGING BACTERIAL ORGANISMS AND ANTIMICROBIAL RESISTANCE PATTERN AMONG HOSPITALIZED COMMUNITY ACQUIRED PNEUMONIA PATIENTS IN A TERTIARY CARE CENTER
[b] BACKGROUND[/b]: Most of the times a Community Acquired Pneumonia (CAP) patient is being treated with empirical antibiotics by best guess method by the clinician.MDR strains are being reported from c/s report...
A COMPARATIVE STUDY OF DEXMEDETOMIDINE AND CLONIDINE TO ATTENUATE HAEMODYNAMIC RESPONSE DURING LARYNGOSCOPY AND INTUBATION
BACKGROUND Laryngoscopy and tracheal intubation after the induction of anaesthesia are nearly always associated with a sympathetic hyperactivity. To attenuate the pressor response various drugs have been tried, but these...
CONVENTIONAL OPEN EARLY APPENDECTOMY IN MANAGEMENT OF APPENDIX LUMP
BACKGROUND Acute appendicitis is one of the most common causes for abdominal emergency worldwide. Its causes vary from the ones requiring medical management to those necessitating surgical intervention. Even though clini...
A STUDY OF PRIMARY ORBITAL IMPLANTS FOLLOWING EVISCERATION SURGERY
BACKGROUND Eye is known to be the most important sensory organ of communication and expression of our feelings. Loss of this organ may lead to impairment of vision, disfigurement and psychological trauma. Evisceration is...