FORMULATION AND EVALUATION OF BILAYER FLOATING TABLET CONTAINING VERAPAMIL HYDROCHLORIDE
Journal Title: International Journal of Pharmaceutical Development & Technology - Year 2013, Vol 3, Issue 1
Abstract
The objective of the present investigation was to develop a bilayer-floating tablet (BFT) for Verapamil Hydrochloride using direct compression technology using floating and viscosity enhancing polymers such as HPMC K100 and Carbopol 940. Sodium bicarbonate and citric acid were used as a gas generating agent. All the bi-layered floating tablet formulations were subjected to post-compression evaluation parameters such as hardness, friability, weight variation, thickness, drug content, lag time subsequently buoyancy time, and in-vitro dissolution studies. The assay of the formulation revealed that the drug content was within the limits. In-vitro floating revealed that all the formulations showed buoyancy of more than 12 hours. Dissolution tests were performed using USP dissolution apparatus at 75 rpm in pH 1.2 buffer. The tablet split in to 2 layers i.e. floating and immediate layer in the dissolution medium, which exhibited biphasic release of Verapamil Hydrochloride. The formulation F3 released 98.24% of drug at the end of 12hr. The invitro drug release data was fitted into various kinetic models and the best fit release kinetics was achieved with Peppas model.
Authors and Affiliations
Asha spandana KM , SK Senthil Kumar , S Parthiban
Keywords
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