Formulation and Evaluation of Swelling Restricted Matrix Tablet Containing Metformin Hcl
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2014, Vol 4, Issue 4
Abstract
: Conventional drug delivery system and is known to provide an immediate release of drug, an alternative to administration of another dose is to use a dosage form that will provide sustained drug release. Metformin Hcl was formulated as restricted swelling matrix tablet by using HPMC K100 and CMC in ratio of 50:50 in order to obtain a sustained release formulation. Matrix tablets containing 500mg of metformin were prepare by direct compression method. From the formulations MFH 12 was selected and given partial coating with cellulose acetate 5% solution in acetone ( MFH 13 & MHF14) to restrict the swelling and hence to retard its release. The drug polymer ration influenced the release of drug from the formulations. An increase in polymer decreased the drug release. F13 partially coated swelling matrix tablet further retarded the release of drug. Formulation F13 with drug polymer (HPMC K100M and CMC) ratio (500:125:125) has shown promising results as per USP test I requirements.
Authors and Affiliations
Deepu S , Dr. (Sr. ) Molly Mathew , Shamna M S
Keywords
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