PELLETIZATION TECHNIQUE IN DRUG DELIVERY SYSTEM- A REVIEW
Journal Title: International Journal of Pharmaceutical Development & Technology - Year 2013, Vol 3, Issue 1
Abstract
In present times, the pelletization technologies are giving much attention as they represent an efficient pathway for manufacture of new drug delivery system .It has good advantage over the conventional dosage form. Pelletization technique help in the formation of spherical beads or pellets having a diameter 0.5 -1.5 mm which can be eventually coated for preparation of modified release dosage form. These pelletized dosage forms have gained popularity considerably from then because of their distinct advantages, such as ease of capsule filling because of better flow properties of the perfectly spherical pellets; enhancement of drug dissolution; ease of coating; sustained, controlled, or site-specific delivery of the drug from coated pellets; uniform packing; even distribution in the GI tract; and less GI irritation. The aim of this study is to provide detailed and different techniques of pelletization. Pelletized dosage forms can be prepared by a number of techniques, including drug layering on nonpareil sugar or microcrystalline cellulose beads, spray drying, spray congealing, roto granulation, hot-melt extrusion, and spheronization of low melting materials or extrusion-spheronization of a wet mass. The techniques namely extrusion-spheronization, hot melt extrusion, freeze pelletization, cryopelletization have been discussed along with formulation requirements for the process, parameters affecting pelletization. Evaluation of quality of the pellets is discussed with reference to the size distribution, shape, surface morphology, specific surface area, friability, tensile strength.
Authors and Affiliations
Veena MC , Senthil Kumar SK , Parthiban S
Keywords
Related Articles
- EP ID EP137121
- DOI -
- Views 82
- Downloads 0
RECENT TRENDS IN INSULIN DRUG DELIVERY SYSTEM
The advanced methods of insulin delivery systems would gradually progress toward physiological insulin replacement and reduce the long-term complications of diabetes mellitus. Thus, a feasible alternative route f...
PHOSPHOLIPON AS A BINDER IN THE FORMULATION OF 4-ACETOMIDOPHENOL TABLETS
ABSTRACT Pharmaceutical manufacturing inform of liposomal delivery has one of the most important approaches to improve the cellular uptake and subsequent bioavailability of drugs and as such phospholipon was chos...
USE OF INORGANIC CHEMICAL & ITS IMPACT ON HUMAN HEALTH: A CASE OF FARMERS IN INDIA
ABSTRACT There was a time when every scientific research had a large importance in society but ignoring its side effects. So some those type of invention are widely accepted which are not eco-friendly. The conven...
NOVEL SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL STUDIES OF SCHIFF BASE COMPLEXES OF 4-PYRIDINE CARBOXALDEHYDE
ABSTRACT In the present study an intermolecular reductive Schiff base formation from 4-nitro pyridine and 4 pyridine carboxaldehyde carried out in the presence of iron powder and dilute acid. The Schiff base and...
DESIGN AND IN VIVO EVALUATION OF GASTROINTESTINAL MUCOADHESIVE PATCH SYSTEM (GMPS) LOADED WITH CHITOSAN NANOPARTICLES
ABSTRACT A novel gastrointestinal mucoadhesive patch system was designed to improve the oral bioavailability of macromolecular therapeutics using chitosan nanoparticles for effective delivery of macromolecules (u...