PHARMACODYNAMIC INTERACTION OF GREEN TEA EXTRACT WITH HYDROCHLOROTHIAZIDE AGAINST ISOPROTERENOL INDUCED MYOCARDIAL DAMAGE IN RATS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2014, Vol 5, Issue 4
Abstract
To evaluate the pharmacodynamic interaction of green tea extract with hydrochlorothiazide against isoproterenol induced myocardial infarction wistar albino rat of either sex were prophylactically treated with hydrochlorothiazide (10 mg/kg for 7 days), low and high dose of green tea extract (100 and 500 mg/kg for 3 weeks) and their combination by oral route. To induce the toxicity apart from normal control all other group subjected to isoproterenol (150 mg/kg, s.c) for two consecutive days. The effect of prophylactic treatment was analyzed by estimation of electrocardiographic changes, serum biomarker levels, antioxidant level in tissue and histopathological report. Green tea in both high and low dose and their combination groups with hydrochlorothiazide significantly reduced the serum biomarker levels, increased antioxidant levels in tissue, restored the electrocardiographic changes compared to isoproterenol only treated group. The combination group showed substantial amount of restoration of all the parameters compared to hydrochlorothiazide alone treated group. To conclude the combination of green tea extract with hydrochlorothiazide reduced the side effect and found to be effective against myocardial stress.
Authors and Affiliations
Manodeep Chakraborty, Jagadish Kamath
THERAPEUTIC AND NUTRITIONAL SIGNIFICANCE OF DUGDHA (MILK) WITH REFERENCE TO COW’S MILK
Godugdha (Cow’s milk) is also elixir of life. Dugdha (milk) is a general term for the milk of any of the animals. In Ayurveda, Cow’s milk is much appreciated for the therapeutic purposes as well as nutrition, so that it...
DETECTION OF MULTIPLE MICROBIAL DNA IN ATHEROMATOUS PLAQUES BY POLYMERASE CHAIN REACTION
The present study was aimed at evaluating the relationship between the presence of microbial infections and cardiovascular disease by testing the atheromatous plaque and non-atheromatous tissue samples. We analyzed pro...
MUTATIONAL BIOASSAY AND AMELIORATIVE ACTION OF CAFFEINE FOR INDUCTION OF EARLY MATURING MUTANT IN NIGELLA SATIVA L.
With the unfolding of mutational studies, chemical mutagenesis is widely used for developing induced mutants in plants. The efficiency of this technique using one of potent chemical mutagen i.e., Caffeine is accounted in...
PHYTOCHEMICAL SCREENING AND IN VITRO FREE RADICAL SCAVENGING ACTIVITY OF ORTHOSIPHON STAMINEUS AND COCCINIA GRANDIS
Oxygen is a highly reactive atom that is capable of becoming part of potentially damaging molecules commonly called “free radicals.” Free radicals are capable of attacking the healthy cells of the body, causing them to l...
SCAFFOLD: TISSUE ENGINEERING AND REGENERATIVE MEDICINE
Scaffolds are the central components, which are used to deliver the cells, drug and gene into the body. Polymeric scaffolds may be prepared as typical 3-D porous matrix, nanofibrous matrix, thermo sensitive sol-gel trans...