PHARMACODYNAMIC INTERACTION OF GREEN TEA EXTRACT WITH HYDROCHLOROTHIAZIDE AGAINST ISOPROTERENOL INDUCED MYOCARDIAL DAMAGE IN RATS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2014, Vol 5, Issue 4
Abstract
To evaluate the pharmacodynamic interaction of green tea extract with hydrochlorothiazide against isoproterenol induced myocardial infarction wistar albino rat of either sex were prophylactically treated with hydrochlorothiazide (10 mg/kg for 7 days), low and high dose of green tea extract (100 and 500 mg/kg for 3 weeks) and their combination by oral route. To induce the toxicity apart from normal control all other group subjected to isoproterenol (150 mg/kg, s.c) for two consecutive days. The effect of prophylactic treatment was analyzed by estimation of electrocardiographic changes, serum biomarker levels, antioxidant level in tissue and histopathological report. Green tea in both high and low dose and their combination groups with hydrochlorothiazide significantly reduced the serum biomarker levels, increased antioxidant levels in tissue, restored the electrocardiographic changes compared to isoproterenol only treated group. The combination group showed substantial amount of restoration of all the parameters compared to hydrochlorothiazide alone treated group. To conclude the combination of green tea extract with hydrochlorothiazide reduced the side effect and found to be effective against myocardial stress.
Authors and Affiliations
Manodeep Chakraborty, Jagadish Kamath
Keywords
Related Articles
- EP ID EP136627
- DOI 10.7897/2230-8407.050463
- Views 108
- Downloads 0
FORMULATION AND EVALUATION OF FAST DISSOLVING NIMESULIDE TABLETS BY SOLID DISPERSION TECHNIQUE
The aim of this study was to prepare fast dissolving tablets of Nimesulide by employing solid dispersion technique. Formulations were evaluated for precompressional parameters such as angle of repose, % compressibility a...
NOVEL ATYPICAL ANTIPSYCHOTIC AGENTS
Antipsychotics are a group of drugs commonly but not exclusively used to treat psychosis. Antipsychotic agents are grouped in two categories: Typical and Atypical antipsychotics. The first antipsychotic was chlorpromazin...
SPHERICAL AGGLOMERATION – DIRECT TABLETTING TECHNIQUE
Direct tabletting technique is the modern and the most efficient process used in tablet manufacturing and has been successfully employed for various poorly soluble and poorly compressible drugs. Spherical agglomeration...
INDIGENOUS EFFECT OF CYNODON DACTYLON IN EXPERIMENTAL INDUCED ULCERS AND GASTRIC SECRETIONS
Cynodon dactylon is a perinneal grass,the plant is a rich source of metabolites such as proteins,carbohydrates mineral constituents, β-sitosterols, flavinoids, alkaloids, glycosides and triterpenoids the plant has been l...
EUPHORBIA NERRIFOLIA LINN: HERBAL TOOL FOR BIRTH CONTROL
In the present study, antifertility activity of hydroalcoholic extract of Euphorbia neriifolia Linn was evaluated. The ethanolic extract of Euphorbia neriifolia showed significant antifertility activity Pre treatment wit...