FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF RANITIDINE HYDROCHLORIDE USING DIFFERENT SUPERDISINTEGRANT
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 10
Abstract
Ranitidine HCl is an H2 anhistaminic drug mainly used for treatment of peptic ulcers and is absorbed 50% orally. The drug undergoes hepatic metabolism, so the attempt has been made to administer it as fast dissolving tablet to increases its oral bioavailability. The tablets were prepared by using sublimation method using ammonium bicarbonate as sublimating agent. The tablets were evaluated for hardness, wetting time, dispersion time, disintegrating time. The other tablets prepared by using sodium starch glycolate and cross carmellose sodium as superdisintegrant. It was concluded that the tablets prepared by super disintergrant addition have better disintegrating properties and release profile when compared to the tablets prepared by sublimation method.
Authors and Affiliations
Dharmendra Sharma , A. K Singhai , G. K Saraogi , Avinash Rajak , Devendra Joshi
Keywords
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