PREPARATION AND EVALUATION OF GASTRORETENTIVE MUCOADHESIVE MICROSPHERES OF CAPTOPRIL
Journal Title: International Journal of Pharmaceutical Development & Technology - Year 2012, Vol 1, Issue 2
Abstract
The aim of the present investigation was to evaluate the potential use of mucoadhesive microspheres for gastroretentive delivery of captopril. Chitosan was used as mucoadhesive polymers. The release of drug was prolonged to 12 h (94.61±0.939) when incorporated into mucoadhesive microspheres. The batches were prepared by using different volumes of the cross-linking agent, and the cross linking time was also varied. From the resulting batches, the volume of the cross linking agent was optimized to 6 ml. and the cross-linking time was optimized to 2 hours, and the polymer and drug concentration was varied. FTIR shows that there is no interaction with. Pure drug, pure chitosan and physical mixture while taken by preparing KBr pellets (Disk method). From the entrapment and dissolution study, it was concluded that batch CM-4 showed sustained release for 12 hrs. The batch was optimized for the sustained release microspheres of Captopril by using Chitosan. Overall, the result indicated prolonged delivery with significant improvement in oral bioavailability of captopril from mucoadhesive microspheres due to enhanced retention in the upper GI tract.
Authors and Affiliations
Shubhrajit Mantry , Arabinda Patnaik , N. Sriram
Keywords
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