PREPARATION AND EVALUATION OF GASTRORETENTIVE MUCOADHESIVE MICROSPHERES OF CAPTOPRIL
Journal Title: International Journal of Pharmaceutical Development & Technology - Year 2012, Vol 1, Issue 2
Abstract
The aim of the present investigation was to evaluate the potential use of mucoadhesive microspheres for gastroretentive delivery of captopril. Chitosan was used as mucoadhesive polymers. The release of drug was prolonged to 12 h (94.61±0.939) when incorporated into mucoadhesive microspheres. The batches were prepared by using different volumes of the cross-linking agent, and the cross linking time was also varied. From the resulting batches, the volume of the cross linking agent was optimized to 6 ml. and the cross-linking time was optimized to 2 hours, and the polymer and drug concentration was varied. FTIR shows that there is no interaction with. Pure drug, pure chitosan and physical mixture while taken by preparing KBr pellets (Disk method). From the entrapment and dissolution study, it was concluded that batch CM-4 showed sustained release for 12 hrs. The batch was optimized for the sustained release microspheres of Captopril by using Chitosan. Overall, the result indicated prolonged delivery with significant improvement in oral bioavailability of captopril from mucoadhesive microspheres due to enhanced retention in the upper GI tract.
Authors and Affiliations
Shubhrajit Mantry , Arabinda Patnaik , N. Sriram
Keywords
Related Articles
- EP ID EP142314
- DOI -
- Views 91
- Downloads 0
DESIGN AND IN VIVO EVALUATION OF GASTROINTESTINAL MUCOADHESIVE PATCH SYSTEM (GMPS) LOADED WITH CHITOSAN NANOPARTICLES
ABSTRACT A novel gastrointestinal mucoadhesive patch system was designed to improve the oral bioavailability of macromolecular therapeutics using chitosan nanoparticles for effective delivery of macromolecules (u...
DESIGN AND EVALUATION OF GELATIN MICROSPHERES CONTAINING DICLOFENAC SODIUM
Microspheres are characteristically free flowing powders consisting of proteins or synthetic polymers which arebiodegradable in nature and ideally having a particle size less than 200 μm. The present study is aimed...
USE OF INORGANIC CHEMICAL & ITS IMPACT ON HUMAN HEALTH: A CASE OF FARMERS IN INDIA
ABSTRACT There was a time when every scientific research had a large importance in society but ignoring its side effects. So some those type of invention are widely accepted which are not eco-friendly. The conven...
PREPARATION AND EVALUATION OF GASTRORETENTIVE MUCOADHESIVE MICROSPHERES OF CAPTOPRIL
The aim of the present investigation was to evaluate the potential use of mucoadhesive microspheres for gastroretentive delivery of captopril. Chitosan was used as mucoadhesive polymers. The release of drug was p...
FORMULATION AND EVALUATION OF EXTENDED RELEASE TABLET OF DIVALPROEX SODIUM USING DIFFERENT POLYMERS AS RELEASE RETARDING AGENT
ABSTRACT The main objective of this work is to investigate the possibility of sustained release dosage forms for the drug Divalproex Sodium by using different polymers like Hydroxy Propyl methyl cellulose, Hydrox...