Probiotics in the treatment of peptic ulcer infected by helicobacter pylory and its safety
Journal Title: Pakistan Journal of Pharmaceutical Sciences - Year 2015, Vol 28, Issue 3
Abstract
This paper aimed to study the curative effect of probiotics in the treatment of peptic ulcer (PU) infected with Helicobacter Pylory (H. Pylory). A total of 132 cases of patients with PU infected by H. Pylory who were received and treated by department of gastroenterology from Binjiang Hospital, Guangxi from May 2013 to 2014 were recruited in the study. They were divided into observation group and control group based on random number table, 66 cases in each group. Patients in observation group were given probiotics combined with triple therapy while patients in control group were treated by traditional triple therapy. After one-month treatment, all the patients were examined by 14C urea breath test for checking the treatment condition of H. Pylory and reviewed by gastroscope for checking union of ulcer. In addition, clinical effect and improvement of digestive tract symptom were compared between two groups. It was found that, the content of 14C urea detected by breath test was 95.15 dpm/mmol±8.34 dpm/mmol in observation group after treatment; eradication rate of H. Pylory was 87.9%; symptom remission rate was 97%; adverse reaction rate was 4.5%; total effective rate of clinical treatment was 97%; while in control group, the content of 14C urea was 100.3 dpm/mmol±10.34 dpm/mmol, eradication rate was 63.6%, symptom remission rate was 93.9%, adverse reaction rate was 18.2%, and total effective rate was 83.3%. These results demonstrated that, the symptom remission rate of the observation group and the control group was not obvious, but the content of 14C urine, eradication rate of H. Pylory, incidence of adverse reaction and total effective rate were of significant significance in two groups (P<0.05). In conclusion, probiotics combined with triple therapy for treating PU infected by H. Pylory can greatly improve the eradication rate of H. Pylory and increase recovery rate of patients, with less adverse reaction. Therefore, the method is worth for promotion.
Authors and Affiliations
Fengzhen Ma , Chao Zhou , Jian Wang , Tonggang Liu , Jiyong Liu
Keywords
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