Seasonal Variation of Circadian Activity of Rat Measured by Circadian Locomotor Modified Cage
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2015, Vol 5, Issue 2
Abstract
Circadian rhythm variations are related to seasonal photoperiodic variations, which affect animal as well as human physiology and behavior. The present study aimed to evaluate the effect of photoperiodic variations on circadian locomotor activity using circadian locomotor modified cages to maintain animals' welfare demands. Twelve male Sprague Dawley rats (140-180g) housed under natural photoluminous periods. Rats were divided into two groups (each, n=6), summer group (Long photoperiod; GA; LD 14:10) and winter group (Short photoperiod; GB; LD 11:13). Circadian locomotor activity rhythm was examined in both groups. Rats were housed individually in circadian locomotor plastic cages with voluntary running wheel. Results revealed that GB rats had significantly (p<0.05) greater locomotor activity during the day and longer tau than GA rats. Locomotor activity of GB significantly (p<0.05) decreased compared to GA. Taken together, it could be concluded that the ability of GA rats to entrain to long photoperiod compared to GB, suggests that the photoperiod affects the circadian locomotor rhythm. Moreover, the present study tried to introduce a design for circadian locomotor modified cage.
Authors and Affiliations
Menatallah M. Mohammed
Keywords
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