Study of therapeutic efficacy of Piper betel Linn with asthma in guinea pig model
Journal Title: Journal of Medical Science and Technology - Year 2016, Vol 5, Issue 1
Abstract
Asthma is a chronic obstructive condition, it is not considered as a part of chronic obstructive pulmonary disease as this term refers specifically to combinations of disease that are irreversible such as bronchiectasis, chronic bronchitis, and emphysema. Male guinea male pigs were selected for the experiment. Animals were weighed with the help of weighing machine. The guinea pigs weighing 450gm on average were selected for the experiment. The study was conducted in MIMS (Maharajah’s Institute of Medical Sciences). In this study evaluated the anti-asthmatic effect of ethanol extract of piper betel Linn in guinea pigs by using histamine chamber 24 guinea pigs were selected and are divided into four groups each containing 6 guinea pigs (i.e., group I, II, III and IV respectively). Comparison of control group with standard group the mean difference of preconvulsive time at 1st hour was -222.50 with 95% confidence interval from -237.26 to -207.74 with a p value of <0.001. Comparision of control group with test - 1 group the mean difference of preconvulsive time at 2nd hour was -195.20 with 95% confidence interval from -229.21 to -161.19 with a p value of <0.001. Bronchial asthma is an inflammatory condition so anti-inflammatory activity of piper betel linn, may be the reason for reducing bronchial asthma. Present study shows protection against histamine induced experimental bronchial asthma in guinea pigs which may be due to anti-inflammatory activity, antioxidant action and antihistaminic action.
Authors and Affiliations
B Kodandaramu, T Chaithanya, Basawaraj Munge, N Ranjitha , Mamata Bandopadhyay
Keywords
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