Synthesis and characterization of amino acid conjugates of oleanolic acid and their in vitro cytotoxic effect on HCC cell lines
Journal Title: Pakistan Journal of Pharmaceutical Sciences - Year 2014, Vol 27, Issue 5
Abstract
Oleanolic acid (3β-hydroxy-olean-12-en-28-oic acid; OA-01), a pentacyclic triterpene, exhibit a wide range of pharmacological ad biological activities. We have isolated oleanolic acid from methanolic extract of Periploca aphylla, collected from surroundings of Karachi in the month of February. Furthermore, four known and two new C-28 amino acid conjugates of oleanolic acid were prepared to explore potential of these compounds on HCCs and one breast cancer cell line. Cytotoxic effects revealed that as compare to parent compound (OA-01), two derivatives OA-04 (p<0.0001) and OA-06 (p<0.01) showed significantly increased /higher inhibition rates.
Authors and Affiliations
Muhammad Ayaz Mustufa , Imran Ali Hashmi , Shahbaz Manzoor , Aamir Ahmed , Viqar-ud-din Ahmed , Afshan Aslam , Cigdem Ozen , Naim ul Hasan Naqvi , Mehmet Ozturk , Firdous Imran Ali
Keywords
Related Articles
- EP ID EP99988
- DOI -
- Views 107
- Downloads 0
Pharmacological rational of dry ripe fruit of Aegle marmelos L. as an anti-nociceptive agent in different painful conditions
The aim of study is to investigate central and peripheral analgesic effects of methanolic extract of dry ripe fruit of Aegle marmelos Linn. Corea (Am. Cr) by two methods, tail flick test and acetic acid induce...
Potent AChE enzyme inhibition activity of Zizyphus oxyphylla: A new source of antioxidant compounds
The purpose of this study was to assess the antioxidant potential and enzyme inhibition of various fractions of Zizyphus oxyphylla. The plant metabolites were extracted in methanol and partitioned with n-hexane, ch...
Dynamic matching algorithm for viral structure prediction
Most viruses have RNA genomes, their biological functions are expressed more by folded architecture than by sequence. Among the various RNA structures, pseudoknots are the most typical. In general, RNA secondary st...
Correction of iron deficiency anemia in pregnancy and its effects on Superoxide dismutase
Iron deficiency anemia (IDA) affects not only the hematological parameters but also disturb the oxidative balance of body. In pregnancy, this is much more considerable as oxidative stress is considered to be one of the p...
Variation in bioactive principles of Artemisia amygdalina Decne. in wild and tissue culture regenerants
Wild and tissue culture raised regenerants of Artemisia amygdalina, a critically endangered and endemic plant of Kashmir and North West Frontier Provinces of Pakistan were screened for the amount of bioactive principles...