TABLETING PROPERTIES OF THERMALLY ACTIVATED COW BONE POWDER IN LOW DOSE FORMULATION

Journal Title: Asian J of Pharm Sci & Tech - Year 2016, Vol 6, Issue 2

Abstract

 ABSTRACT Formulations of low dose drugs into a tablet dosage form require appropriate diluents in a significant quantity that may enhance the ease of handling. Activated cow bone powder was evaluated and found suitable as a diluent in the formulation of low and high dose drugs. This study was conducted in order to compare the diluent properties of dicalcium phosphate (DCP) and activated bone powder (ABP) in the formulation of low dose drugs. The mixed powders were pelletized with the specac pelletization machine, using a compaction force between 10-20 metric tonnes. The weights of 250 mg of granules were put in the die of 8.5 mm punch and were compressed using Erweka single station tableting machine. The formulated folic acid tablet was evaluated for properties such as weight uniformity, thickness, crushing strength, friability, disintegration and organoplastic. Assay of the tablet was done using spectrophotometric analysis. Of interest in this formulation is the assay which gave as much as 96% content and the weight variation which is below 2%. In all the formulations, ABP compressibility was higher than that of DCP. The disintegration times were within the acceptable time limit. The hardness of the tablets containing same formulation with ABP compared with DCP was higher in all cases. The friability values generally were lower than 1%, which is the limit accepted by pharmaceutical industries. Analysis of the granule size distribution of the pellets gave a mean granule size (MGS) of 442µm. The disintegration time and the friability values for all tablets from the single station tablet machine and the pelletizer were all within the acceptable official limits. Activated bone powder was found to be better direct compressible diluents than the commercially available dicalcium phosphate for low dose drugs such as folic acid. Key words: Formulation, Folic acid, Activated bone powder.

Authors and Affiliations

Emenike IV*, Ibrahim YKE, Timothy SY, Musa H

Keywords

Related Articles

 DEVELOPMENT OF ANALYTICAL METHOD FOR PYRANTEL EMBONATE USING UV-SPECTROPHOTOMETRY

 ABSTRACT A simple, sensitive, specific, spectrophotometric method has been developed for the detection of pyrantel embonate in pure form and pharmaceutical dosage forms. The optimum condition for the analysis of...

 A REVIEW: TRANSUNGAL DRUG DELIVERY A NEW AND NOVEL SYSTEM

 ABSTRACT The Nail preparations are widely used in cosmetic preparations for enhancing the beauty of nails. Conventional nail lacquers generally consist of solvents, film forming polymers, resins and plasticizers....

 ANTINOCICEPTIVE EFFECTS OF STIGMASTEROL AND 9-HEXACOSENE ISOLATED FROM MONDIA WHYTEI (HOOK.F.) ROOT

 ABSTRACT Mondiawhytei is used for treatment of dysmennorrhea, gastro intestinal colic, post partum pains among other uses in the practice of traditional medicine in Africa. In the present study, the in vivoantin...

 MICROBIAL CONVERSION OF SUGAR CANE PHYTOSTEROLS BY FUSARIUM SOLANI

 ABSTRACT Air dried press cake of sugar cane (5 Kg) yielded on extraction with cold acetone 500 g of waxy residue which gave on saponification 150gm. Un-saponifiable matter. Gas chromatography and mass spectroscop...

 ADONIS AESTIVALIS: PHARMACOLOGICAL AND TOXICOLOGICAL ACTIVITIES - A REVIEW

 ABSTRACT Adonis aestivalis (summer pheasant's eye) is an annual plant with herbaceous growth. Although Adonis aestivalis has low concentrations of cardiac glycosides and it can be used therapeutically, but it rem...

Download PDF file
  • EP ID EP133663
  • DOI -
  • Views 163
  • Downloads 0

How To Cite

Emenike IV*, Ibrahim YKE, Timothy SY, Musa H (2016).  TABLETING PROPERTIES OF THERMALLY ACTIVATED COW BONE POWDER IN LOW DOSE FORMULATION. Asian J of Pharm Sci & Tech, 6(2), 63-70. https://europub.co.uk/articles/-A-133663