UTILITY OF ORAL AND VAGINAL MISOPROSTOL IN THE INDUCTION OF LABOUR: A COMPARATIVE STUDY
Journal Title: Int J of Pharm Res & Analy - Year 2014, Vol 4, Issue 1
Abstract
This study was conducted to compare the efficiency and safety of oral (50 μg) and vaginal (25 μg) misoprostol for labour induction. In this study one Hundred patients with indications for labour induction randomly received 50 μg oral misoprostol every 4 h or 25 μg vaginal misoprostol every 4 h, using maximum four doses. Mean induction time, mode of delivery, rates of tachysystole, oxytocin use, number of doses used, failed induction rate and Intrapartum complication with fetal outcomes were compared for the two groups. Mean dose of misoprostol used for oral and vaginal misoprostol study populations were 2.34 ± 1.05 and 1.96 ± 0.91, respectively. There were two failed inductions in the oral (4%) and one failed induction (2%) in the vaginal group after a total of six doses of misoprostol. Our findings indicated that, 50 μg oral misoprostol has the potential to induce labor as safely and effectively as its 25 μg vaginal analogue. Oral ingestion of misoprostol being easier for the patient and the doctor, orally administered is more preferable than the vaginal route.
Authors and Affiliations
Kamath Rajalaxmi K , Srikar SV
Keywords
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