Neourodynamics in patient with Alzheimer’s disease during working memory task
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2017, Vol 5, Issue 8
Abstract
Abstract:The aim of the present study was to evaluate the behaviour of memory-related electroencephalographic measures in patients with Amnesic Alzheimer’s disease. Electroencephalography (EEG) was recorded during working memory test (LB-memory test) in age-sex matched 30 normal elderly subjects and 20 amnesic Alzheimer’s disease patients (55-75 years). The EEG bands so evaluated were delta (0.2-3.9 Hz), theta (4.0-7.9 Hz), alpha (8.1- 12.9 Hz), beta (13.0 -30.0 Hz) and gamma (30.1-80 Hz). A significant decrease Mini Mental State Examination (MMSE) score was observed in patients when compared to controls (p=0.000). Amnesic Alzheimer’s patients showed significant decreased working memory scores in List A (p=0.038), List B (p=0.003) and List C (p=0.000), decreased absolute power in delta, theta, alpha, beta and gamma in fronto-central and temporal regions and significant decreased coherence in frontal (F3-F4) and temporal (T3-T4) lobes in alpha-1(8-9.9 Hz), alpha-2 (10-12.9 Hz) and beta (13-30 Hz) bands (p=0.000) during working memory task as compared to healthy, age and sex matched control subjects. These results suggest that absolute power and coherence during working memory task can discriminate Amnesic Alzheimer’s patients from normal elderly subjects. Keywords:AmnesicAlzheimer’s disease, Electroencephalography (EEG), Mini Mental State Examination (MMSE), working memory task, Absolute power, Coherence
Authors and Affiliations
Sweta Soni, Amitabh dube
Keywords
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