Neuro-protective role of seeds of Mucuna pruriens BEK and Mucuna monosperma DC in wistar albino rats
Journal Title: The Journal of Phytopharmacology - Year 2015, Vol 4, Issue 6
Abstract
Mucuna pruriens Bek. and Mucuna monosperma DC. seeds were extensively used in Ayurveda for neuromuscular disorders. The objective of present study was to screen the neuroprotective activity of the test drugs in wistar albino rats. The cerebral ischemia was induced by bilateral common carotid artery occlusion for 60 minutes followed by reperfusion. At the end of the experiments under anaesthesia animals were sacrificed and brain was removed. Anti oxidant and histopathological examination was carried out of the brain tissue. Both test drugs have been shown considerable anti oxidant activity in comparison to BCCAO control group. Histopathological examination revealed there is a decreased cellularity and predominance of immature neurons in the granular layer was observed in hypothalamus in control rats while the test drug has shown normal cytoarchitecture. The sections of hippocampus from Mucuna monosperma DC group exhibited decreased cellularity of the granular layer and vacuolization was observed and Mucuna pruriens Bek treated group exhibited almost normal cytoarchitecture. In conclusion the test drugs possess moderate anti oxidant and cellular integrity maintaining potential in different brain regions and hence it supports its therapeutic claim in neuromuscular disorders.
Authors and Affiliations
Desai Yogesh Hareshchandra, Ravi Mundugaru, Shridhara Bairy T, Ravikrishna S, Ravi Shankar B
Keywords
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