Neurological adverse drug reactions of anticancer drugs
Journal Title: International Journal of Research in Pharmacology & Pharmacotherapeutics (IJRPP) - Year 2014, Vol 3, Issue 3
Abstract
Aim: The aim of this study was to analyze the neurological adverse drug reactions of anticancer drugs that were reported to adverse drug reaction monitoring centre. Methods:The entire neurological adverse drug reactions (ADRs) reported with anticancer drugs, received through spontaneous reporting system and active surveillance method from January 2012 to September 2013 were analyzed for demographic profile, ADR pattern, severity and causality assessment. Results: During the study period, a total of 1418 anticancer drug related ADRs were obtained from 1076 patients; among them 84 (5.9%) reactions were neurological. Totally 77 patients developed 84 neurological ADRs. Among them 42 were males (54.5%) and 35 were females (45.5%). CAPOX (Capecitabine and oxaliplatin) was the leading drug regimen among agents causing neurological ADRs accounting for 15.5%. The most frequently reported ADR was neuropathy (72.6%). According to WHO causality assessment of ADRs, majority of the reports come under possible (89.6%) category. Hartwig severity scale showed that 57.1% of the reactions were moderately severe. Conclusion: The frequency of neurological adverse drug reactions of anticancer drugs obtained was found to be 5.9%. Capecitabine and oxaliplatin regimen is the major causative agent among the anticancer drugs for neurological ADRs. Our study provided the analysis of neurological ADRs occurring due to anticancer agents.
Authors and Affiliations
M Palaniappan M Palaniappan
Keywords
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