Neuroprotective antioxidant effect of sex steroid hormones in traumatic brain injury
Journal Title: Pakistan Journal of Pharmaceutical Sciences - Year 2012, Vol 25, Issue 1
Abstract
: The aim of the present study was to evaluate the effect of different doses of sex steroid hormones on brain edema, BBB permeability, brain antioxidant enzyme activity, and MDA level after traumatic brain injury (TBI) in ovarectomized (OVX) rats. Female rats were divided into six (One sham and 5 TBI) groups including: vehicle, estrogen in physiologic (33.3 µg/kg) and pharmacologic (1mg/kg) doses, progesterone in physiologic (1.7 mg/kg) and pharmacological doses (8mg/kg). The results showed that compared to vehicle group, estrogen and progesterone groups showed significantly lower brain water content (P<0.001). Evans blue content was significantly lower in both estrogen doses and in progesterone physiologic dose (P<0.001). Evans blue content was significantly higher in progesterone pharmacologic dose (P<0.001). Superoxide dismutase (SOD) activity was significantly higher in estrogen and progesterone pharmacologic doses (P<0.001). Glutathione peroxidase (GPx) activity was significantly lower in estrogen physiologic dose (P<0.001). It was concluded that the neuroprotective effect of different doses of sex steroid hormones after TBI, may be mediated by changes in oxidant agent activity.
Authors and Affiliations
Nader Shahrokhi , Mohammad Haddad, Siavash Joukar, Mohammad Shabani, Zekie Keshavarzi, Bidoallah Shahozehi
Keywords
Related Articles
- EP ID EP160828
- DOI -
- Views 104
- Downloads 0
Effect of risk factors like age, gender, hypertension, diabetes, smoking, dyslipidemia on coronary artery disease in Karachiites with angiographical data of local population: Number, site, severity of coronary lesion
The aim of this study was to determine the effect of major risk factors like age, gender, hypertension, diabetes, smoking, dyslipidemia on coronary artery disease in Karachiites and highlighted the angiographic dat...
Effect study of sex hormone in the multiple sclerosis of common neurological disorders
Multiple sclerosis (MS) is one of most common neurological disorders, mainly affecting women. The central nervous system (CNS) of this autoimmune disease is characterized by intermittent or chronic damage to the my...
Ameliorating effects of proglumide on neurobehavioral and biochemical deficits in animal model of status epilepticus
Status epilepticus (SE) is a recurrent generalized convulsion condition and is regarded as a medical emergency with around 50% of the cases occurring in children. Besides neurobehavioral and motor deficits, SE is r...
Effect of leaf extracts of Taraxacum officinale on CCl4 induced Hepatotoxicity in rats, in vivo study
Taraxacum officinale L is a medicinal plant, which has enormous medicinal values against various types of liver disorders and it has traditionally been used for the treatment of liver problems by people from the So...
Effects of propolis on blood biochemical and hematological parameters in nitric oxide synthase inhibited rats by Nω-Nitro-L-arginine methyl ester
This study showed the effects of propolis on biochemical and hematological parameters in chronic nitric oxide synthase inhibited rats by Nω-Nitro-L-arginine methyl ester (L-NAME). Rats are given L-NAME for 15 days...