Nevirapine induced Stevens Johnson Syndrome
Journal Title: Journal of Pharmacovigilance and Drug Research - Year 2020, Vol 1, Issue 20201206
Abstract
A 56-year-old male patient presented with a complaint of lesions all over the body with a burning sensation for 4 days. He was on an ART regimen, containing zidovudine, lamivudine, and efavirenz combination for 4 years. But patient accidentally started nevirapine and after 10 days he developed maculopapular lesions which were diagnosed as SJS syndrome. There was a history of rash with nevirapine when ART was started initially in 2012. This incident of an adverse event could be assigned a term "probable" according to the WHO-UMC scale for causality assessment as the re-challenge was found positive. Severe and life-threatening SJS is more common with nevirapine than with other NNRTIs. Physicians and patients must be aware of this adverse effect on early diagnosis and treatment.
Authors and Affiliations
Himani Prajapati1, Neetu Bala2*, Dinesh Kansal2
Drug Related Problems on Anti-platelets and Anti-coagulants in Stroke
The aim of the research work is to access, evaluate and monitor the drug related problems on antiplatelet and anticoagulants in stroke patients. Antiplatelet agents prevent platelets from dumping and prevent clots from f...
A Review on Potential Drug Delivery System as a Treatment of Intercellular Bacterial Infection
Intracellular bacterial pathogens are hard to treat because of the inability of conventional antimicrobial agents belonging to widely used classes, like aminoglycosides and β-lactams, fluoroquinolones, or macrolides to p...
Nevirapine induced Stevens Johnson Syndrome
A 56-year-old male patient presented with a complaint of lesions all over the body with a burning sensation for 4 days. He was on an ART regimen, containing zidovudine, lamivudine, and efavirenz combination for 4 years....
Risk-benefit associated with Azithromycin: A brief review
Azithromycin is the most popular prescribed antimicrobial agent around the world. It comes under the class of macrolide antibiotics. Because of its higher efficacy, tolerance, and broad-spectrum activity, it is primarily...
Design, synthesis, characterization and in vivo studies of some hydroxylated chalcone derivatives as hypoglycemic agents
Low molecular weight ligands (LMWL) have citadel reputation in the modulation of numerous therapeutic targets as a result of their smart uniqueness. The hydroxylated chalcone derivatives have been reported to be therapeu...