NEW FRONTIERS OF TARGET THERAPY IN ONCOLOGY: ACUTE PROMYELOCYTIC LEUKEMIA
Journal Title: Acta Facultatis Medicae Naissensis - Year 2014, Vol 31, Issue 1
Abstract
By introduction of all-trans retinoic acid (ATRA) in de novo acute promyelocytic leukemia (APL) an revolution in therapy of this disease has been made. The rate of molecular complete remissions (CR) have been doubled compared to conventional chemotherapy with anthracyclines ranging from 90% to 95%. Consolidation therapy is required in order to reduce the risk of early relapse. Maintenance therapy is recommended as it further reduces the risk of relapse, especially in high-risk patients. The relapse rate in APL is relatively high, about 30% and is the most common within three years of starting the treatment. Another agent, arsenic trioxide (ATO) is the optimal drug that achieves high CR rate in relapsed, approximately 80% and hematopoietic stem cell transplantation (HSCT) may prolong the overall survival in patients with APL. ATRA and ATO have become a paradigm of targeted therapy, and APL is a paradigm of curable disease, at least in comparison to other forms of acute myeloid leukemia (AML).
Authors and Affiliations
Ivan Petković, Ivica Pejčić, Svetislav Vrbić
Keywords
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- EP ID EP157470
- DOI 10.2478/afmnai-2014-0002
- Views 128
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